Nicholas M. Allen results 24
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SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Pre‐existing phytoplankton biomass concentrations shape coastal plankton response to fire‐generated ash leachateNARA Subscribed
Climate‐driven warming is projected to intensify wildfires, increasing their frequency and severity globally. Wildfires are an increasingly significant source of atmospheric deposition, delivering nutrients, organic matter, and trace metals to coastal and open ocean waters. These inputs have the potential to fertilize or inhibit microbial growth, yet their ecological impacts remain poorly understood. This study examines how as...
Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R packag...
Timely detection and understanding of causes for population decline are essential for effective wildlife management and conservation. Assessing trends in population size has been the standard approach, but we propose that monitoring population health could prove more effective. We collated data from 7 bottlenose dolphin ( Tursiops trun catus) populations in the southeastern United States to develop a method for estimating surv...
Human induced pluripotent stem cells (hiPSCs) have been widely used in cardiac disease modelling, drug discovery, and regenerative medicine as they can be differentiated into patient-specific cardiomyocytes. Long QT syndrome type 3 (LQT3) is one of the more malignant congenital long QT syndrome (LQTS) variants with an SCN5A gain-of-function effect on the gated sodium channel. Moreover, the predominant pathogenic variants in LQ...
Abundance patterns of mammals across Russia explained by remotely sensed vegetation productivity and snow indicesNARA Subscribed
Aim Predicting biodiversity responses to global changes requires good models of species' distributions. Both environmental conditions and human activities determine population density patterns. However, quantifying the relationship between wildlife population densities and their underlying environmental conditions across large geographical scales has remained challenging. Our goal was to explain the abundances of mammal specie...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Human pluripotent stem cells (hPSCs) are a powerful tool for modelling human development. In recent years, hPSCs have become central in cell-based therapies for neurodegenerative diseases given their potential to replace affected neurons. However, directing hPSCs into specific neuronal types is complex and requires an accurate protocol that mimics endogenous neuronal development. Here we describe step-by-step a fast feeder-fre...
Uterine fibroids are benign tumors of the uterus affecting up to 77% of women by menopause. They are the leading indication for hysterectomy, and account for $34 billion annually in the United States. Race/ethnicity and age are the strongest known risk factors. African American (AA) women have higher prevalence, earlier onset, and larger and more numerous fibroids than European American women. We conducted a multi-stage genome...
Detecting spatial regimes in ecosystemsNARA Subscribed
Research on early warning indicators has generally focused on assessing temporal transitions with limited application of these methods to detecting spatial regimes. Traditional spatial boundary detection procedures that result in ecoregion maps are typically based on ecological potential (i.e. potential vegetation), and often fail to account for ongoing changes due to stressors such as land use change and climate change and th...
RTP801 Is Involved in Mutant Huntingtin-Induced Cell DeathNARA Subscribed
Ecological structures and processes occur at specific spatiotemporal scales, and interactions that occur across multiple scales mediate scale‐specific (e.g., individual, community, local, or regional) responses to disturbance. Despite the importance of scale, explicitly incorporating a multi‐scale perspective into research and management actions remains a challenge. The discontinuity hypothesis provides a fertile avenue for ad...
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