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Physics-based 3D ground motion simulations of the 1703 L’Aquila earthquake: from historical reconstruction to seismic scenariosNARA Subscribed
The city of L’Aquila (central Italy) and its surrounding villages have been struck several times throughout history by strong earthquakes, most recently by the $$M_w$$ M w 6.1 event of April 6, 2009. Previously, on February 2, 1703, L’Aquila was partially destroyed by a $$M_w$$ M w 6.7 earthquake, which has remained in the city’s collective memory as the Grande Terremoto (“Big Earthquake”). In this paper, we present a physics-...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Jellyfish (Scyphozoa and Hydrozoa) as natural environmental DNA samplers: a case study in the Northern Adriatic seaNARA Subscribed
Conservation management, aimed at mitigating the ongoing biodiversity loss, critically relies on ecosystem monitoring to enable accurate estimates of species distributions and population sizes. Environmental DNA (eDNA) analysis has become increasingly popular for non-invasive and high-throughput species assessment, including fish species diversity. Beyond the established sample collection protocols, natural samplers of eDNA (n...
Planning and managing for resilient natural resources and communities in the USA: the EPA OrganonNARA Subscribed
The EPA Organon is a collaborative framework for resilience planning created by the U.S. Environmental Protection Agency (EPA) to advance partner-centered collaborations to protect human health and the environment. An “organon” is a thought instrument, and in the case of the EPA Organon is comprised of an organizing structure, guiding principles, information resources, and project examples that are used to improve coordinated...
Following rapid climate change, tundra plant communities are experiencing extensive compositional shifts. A conservation concern is the potential encroachment of boreal species into the tundra (‘borealisation’). Tundra borealisation has been sporadically reported, but not systematically quantified. Here, we synthesised data from across 32 study areas, spanning 1137 plots and 287 vascular plant species, resurveyed between 1981...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Multiple Pleistocene refugia for Arctic Bell‐Heather revealed with genomic analyses of modern and historic plantsNARA Subscribed
Aim Arctic plants survived the Pleistocene glaciations in unglaciated refugia. The number, ages, and locations of these refugia are often unclear. We use high‐resolution genomic data from present‐day and Little‐Ice‐Age populations of Arctic Bell‐Heather to re‐evaluate the biogeography of this species and determine whether it had multiple independent refugia or a single refugium in Beringia. Location Circumpolar Arctic and Coas...
The idea of Africa Alive Corridors (AAC) evolved from Gondwana geological mapping to a comprehensive, more inclusive and dynamic approach to transdisciplinary research known as Earth Stewardship Science. Twenty designated corridors explore the geo-biological and cultural heritage of different regions of Africa over various periods, from deep time to the Anthropocene. Each corridor reveals a specific lens through which to inves...