P. P. Gil results 178
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HTLV-1 infection causes chronic immune activation and a prolonged asymptomatic phase, but the functional features that define early disease remain unclear. We evaluated whether spontaneous proliferation (SP) and related functional immune parameters can distinguish clinical stages across the HTLV-1 spectrum. Spontaneous and mitogen-induced lymphoproliferation (PHA, anti-CD3), measured by CFSE dilution, and in vitro cell death,...
Authigenic grey monazite from Ordovician metasediments of the Iberian massif: the Matamulas placerNARA Subscribed
Authigenic nodular monazite occurs in dark, Middle Ordovician, low-grade metapelites of the Central Iberian and West Asturian-Leonese Zones of the Iberian Massif. Erosion of monazite-bearing slates and phyllites, and short-range transport resulted in localised recent alluvial deposits rich in millimetre-size monazite, of which the Matamulas site, within the Central Iberian Zone, represents one of the most extensive and potenti...
Population Genomic Analyses Reveal Geographic Structure in Rhizoctonia solani AG1 ‐ IA Isolates Associated With Agronomic CropsNARA Subscribed
Soilborne fungal pathogens threaten food security, but limited knowledge of their population biology, including genetic variability and population structure, hinders the development of effective strategies to prevent crop losses. Rhizoctonia solani AG‐1 is a significant soilborne pathogen worldwide, divided into subgroups based on host range and molecular diversity. Rhizoctonia solani AG1‐IA causes sheath blight in rice and ae...
Key factors of the deranged antiviral response in elderly patients with COVID-19: a machine-learning analysisNARA Subscribed
Age is a well-known risk factor to develop severe viral respiratory infections, including severe COVID-19. This study aimed to identify the biological alterations linked to severe disease in elderly patients with COVID-19. For this purpose, we employed a derivation cohort with 450 SARS-CoV-2 infected and unvaccinated patients admitted to hospital wards and a validation cohort with 244 SARS-CoV-2 infected and unvaccinated patie...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Assessment of Bottom Trawl Impacts on the Status of Seabed Communities in European SeasNARA Subscribed
Bottom trawling affects seabed habitats, but its large‐scale impacts remain poorly quantified. Assessment of trawling impacts is essential to support monitoring and achieving sustainability objectives under international conventions, sustainable development goals, and seafood certification programs. We present a Europe‐wide quantitative assessment of bottom trawling impacts, accounting for regional seabed‐community sensitivity...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
A case for monitoring fungi of clinical relevance at beaches: enterococci measures do not correlate with all disease risksNARA Subscribed
Fungal disease is on the rise, coupled with fungal pathogens increasing in geographic range. Studies have shown that viable fungal pathogens may be present in beach sand and water, and consequently, efforts are ongoing in Europe to develop guidelines for fungi levels at beaches. In the USA, fungal diseases are a growing concern, and yet, they are not subject to public health reporting, and beach environments are currently not...
The Missing Global South in Climate Change Biology: Towards Equitable Knowledge Inclusion for Effective Global SolutionsNARA Subscribed
Over the last decades, climate change biology has become a central field in global science, yet knowledge production and its inclusion in global strategies remain profoundly unequal. Our bibliometric analysis of over 580,000 records shows that ~80% of author affiliations come from Global North institutions, meaning that research agendas, theoretical frameworks, and priorities are still largely shaped outside the regions with t...
Preclinical research in obesity-associated metabolic diseases using in vitro, multicellular, and non-mammalian modelsNARA Subscribed
Addressing the physiological effects of bioactive compounds in metabolic diseases (i.e., obesity, diabetes, liver steatosis) and establishing their mechanisms of action have been a major interest for the last decades. However, methodologies that can be applied to achieve this can vary greatly, leading to a limited type of information. Thus, the accuracy, robustness, reliability and potential (human) translation are highly reli...
Exploring In Vitro Mesenchymal Stem Cell Osteodifferentiation via Vibrational Microspectroscopy: A ReviewNARA Subscribed
The application of vibrational microspectroscopy to the study of in vitro mesenchymal stem cells (MSC) osteogenic differentiation is a promising approach towards the understanding of the molecular processes involved in bone fabrication. Both infrared (IR) and Raman microspectroscopies have been applied, with a clear predominance of the latter. Bone marrow MSC have been the target of most studies, followed by those originating...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Due to the heterogeneous nature of soil pore structure, processes such as nitrification and denitrification can occur simultaneously at microscopic levels, making prediction of small-scale nitrous oxide (N 2 O) emissions in the field notoriously difficult. We assessed N 2 O+N 2 emissions from soils under maize ( Zea mays L .) , switchgrass ( Panicum virgatum L.), and energy sorghum ( Sorghum bicolor L.), three potential bioene...