[ 11 C]COU is a trapped metabolite radiotracer for in vivo analysis of Monoamine Oxidase B activity using positron emission tomography (PET) imaging. [ 11 C]COU has the potential to quantify astrocytosis in the early stages of Alzheimer’s disease, providing an earlier marker of disease than currently available for staging disease progression. Prior preclinical studies have demonstrated the efficacy of this radiotracer in precl...

To evaluate the fertility of porphyry mineralization in the Delamerian Orogen (South Australia), zircon and apatite from four prospects, including Anabama Hill, Netley Hill, Bendigo, and Colebatch, have been analyzed by LA-ICP-MS and electron microprobe. The zircon is characterized by heavy REEs enrichment relative to light REEs, high (Ce/Nd) N (1.3–45), and weak to moderate negative Eu/Eu* (0.2–0.78). The apatite has right-sl...

Within and among species variation in trophic and habitat shifts with body size can indicate the potential adaptive capacity of species to ecosystem change. In Arctic coastal ecosystems, which experience dramatic seasonal shifts and are undergoing rapid change, quantifying the trophic flexibility of coastal fishes with different migratory tactics has received limited attention. We examined the relationships among body length a...

Fire–vegetation feedbacks potentially maintain global savanna and forest distributions. Accordingly, vegetation in savanna and forest ecosystems should have differential responses to fire, but fire response data for herbaceous vegetation have yet to be synthesized across biomes. Here, we examined herbaceous vegetation responses to experimental fire at 30 sites spanning four continents. Across a variety of metrics, herbaceous v...