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RPGRorf15 nanopore long-read sequencing improves retinitis pigmentosa molecular diagnosis for men and womenNARA Subscribed
RPGR (Retinitis Pigmentosa GTPase Regulator ) is the main gene involved in X-linked retinitis pigmentosa (RP) and up to 28% of sporadic RP. Pathogenic variants are mostly located in its retina-specific transcript, RPGRorf15 , especially in the terminal exon named open reading frame 15 (ORF15) , which is a highly repeated region. Because of this complex sequence, first- and second-generation short-read sequencing are difficult,...
This study sought to evaluate the characteristics of clinical-pharmacological (CP) medication reviews conducted by the Institute for Clinical Pharmacology of Hannover Medical School for older, multimorbid, polymedicated insurants of the German statutory health insurance fund Kaufmännische Krankenkasse (KKH). Special emphasis was put on potential sex-specific differences between female and male insurants, prescriptions of poten...
Heterospecific social behavior in primates: insights into the evolutionary roots of pet-keepingNARA Subscribed
Primate interspecific interactions with both other primates and non-primate species range from predator–prey dynamics to affiliative behaviors such as grooming, play, and carrying. While many primates participate in interspecific associations or commensal relationships, to our knowledge interspecific social interactions have never been systematically synthesized. Here, we present the first comprehensive review of such interact...
When South Meets North: A Joint Contact Zone Coinciding With Environmental Gradients in Three Boreal Tree SpeciesNARA Subscribed
Post‐glacial recolonisation of Fennoscandia created secondary contact zones in many species, offering opportunities to study how gene flow and selection contribute to their establishment and maintenance. Here, we analyse genomic data from three boreal tree species— Picea abies , Betula pendula and Pinus sylvestris —sampled along a latitudinal gradient in Sweden. Despite differences in colonisation timing and dispersal ecology,...
Coastal managers worldwide must prepare for changes in annual wave overtopping events due to climate change and sea-level rise. Research often assesses overtopping discharges by extreme events at a sea wall crest, typically using data from physical models or empirical rules based on scaled experiments. Here, we analyse a unique 1-year field dataset of coastal wave overtopping, from SW England, to determine the number of indivi...
Aim Future species distributions were modelled to assess the distributional changes of 1692 plant species according to several scenarios. Species vulnerability was calculated according to their red list and native statuses using a new index to better understand the most vulnerable groups of species to future conditions and improve conservation actions. Location Greater Geneva region between France and Switzerland. Time Period...
Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R packag...
Conservation measures require accurate estimates of density and abundance and population trend assessments. The bonobo ( Pan paniscus ) is considered Endangered in the IUCN Red List. This classification assumes that available population data are representative. However, with only 30% of the bonobo’s historic geographical range surveyed, reliable information is needed to assess the species' population status. Here, we use infor...
Dominance and rarity in tree communities across the globe: Patterns, predictors and threatsNARA Subscribed
Aim Ecological and anthropogenic factors shift the abundances of dominant and rare tree species within local forest communities, thus affecting species composition and ecosystem functioning. To inform forest and conservation management it is important to understand the drivers of dominance and rarity in local tree communities. We answer the following research questions: (1) What are the patterns of dominance and rarity in tree...
Recurrent hybridization and gene flow shaped Norway and Siberian spruce evolutionary history over multiple glacial cyclesNARA Subscribed
Most tree species underwent cycles of contraction and expansion during the Quaternary. These cycles led to an ancient and complex genetic structure that has since been affected by extensive gene flow and by strong local adaptation. The extent to which hybridization played a role in this multi‐layered genetic structure is important to be investigated. To study the effect of hybridization on the joint population genetic structur...
Geography and ecology shape the phylogenetic composition of Amazonian tree communitiesNARA Subscribed
Aim Amazonia hosts more tree species from numerous evolutionary lineages, both young and ancient, than any other biogeographic region. Previous studies have shown that tree lineages colonized multiple edaphic environments and dispersed widely across Amazonia, leading to a hypothesis, which we test, that lineages should not be strongly associated with either geographic regions or edaphic forest types. Location Amazonia. Taxon A...
Reading tea leaves worldwide: Decoupled drivers of initial litter decomposition mass‐loss rate and stabilizationNARA Subscribed
The breakdown of plant material fuels soil functioning and biodiversity. Currently, process understanding of global decomposition patterns and the drivers of such patterns are hampered by the lack of coherent large‐scale datasets. We buried 36,000 individual litterbags (tea bags) worldwide and found an overall negative correlation between initial mass‐loss rates and stabilization factors of plant‐derived carbon, using the Tea...
This paper presents a biomechanical study of stems of two liana species, Clematis vitalba and Vitis vinifera , investigates the mechanical performance of these two liana species and attempts to enhance the understanding of structure–function relationships. The investigation involved mechanical testing of whole plant stems, supplemented by X-ray micro-CT (X-ray computed tomography at micron voxel size) imaging and 2D microscopi...
Hybridization mediated range expansion and climate change resilience in two keystone tree species of boreal forestsNARA Subscribed
Current global climate change is expected to affect biodiversity negatively at all scales leading to mass biodiversity loss. Many studies have shown that the distribution of allele frequencies across a species' range is often influenced by specific genetic loci associated with local environmental variables. This association reflects local adaptation and allele changes at those loci could thereby contribute to the evolutionary...