Previous study demonstrated that Hypnea cervicornis lectin (HCA) reduces inflammation and nociception via interaction with the lectin carbohydrate-binding site, modulating gene expression of the interleukins IL-1β, TNF-α and of iNOS. This study evaluated the effect of HCA in the rat model of arthritis induced by zymosan in the tibiotarsal joint and the involvement of macrophage-derived mediators. In vitro, macrophages were sti...

Bokermannohyla frogs comprise species distributed across different Brazilian biomes, several of which are currently listed as endangered species. These anurans host a diversity of parasites that may negatively affect their survival. Several tick species of the family Argasidae and chigger mites of the family Leeuwenhoekiidae exhibit host specificity toward this group. Here, we report a case of co-parasitism by argasid ticks an...

The pygmy ( Kogia breviceps ) and dwarf ( Kogia sima ) sperm whales are cryptic cetaceans characterized by inconspicuous surfacing behavior, small group sizes, and deep‐diving habits, making visual detection particularly challenging. Here, we present the first broad‐scale passive acoustic monitoring (PAM) assessment of Kogia spp. occurrence along the Brazilian coast, spanning both the Equatorial Atlantic Ocean (EAO) and Southw...

Organotellurium (OTe) compounds have pharmacological properties, including leishmanicidal, antimalarial, and antifungal activities. Herein, we assessed cytotoxicity effects of OTe RF07 in a panel of tumor cell lines, as well as its oxidative, toxicity, and hemolytic actions. The toxicity was evaluated on Allium cepa and Artemia salina larvae. Cell viability was also assessed by resazurin in murine cells (Sarcoma 180), human ce...

Purpose Dysphagia in neurological patients complicates oral drug administration. Manual preparation of lozenges/troches lacks precision and scalability. This study investigates the feasibility of implementing a pharmaceutical 3D printer in a hospital pharmacy for the automated production of personalized baclofen troches. Methods Baclofen troches were manufactured in a hospital pharmacy setting, both manually and via pharmaceut...

The tongue is a highly specialized organ whose structural organization reflects functional adaptations related to feeding, grooming, and sensory perception. Although the morphology of the adult domestic cat tongue is well documented, information concerning its prenatal development remains scarce. This study aimed to characterize the macroscopic, microscopic, and ultrastructural development of the lingual epithelium in domestic...

The skin microbiome of humpback whales harbours diverse microbial communities that play a crucial role in host skin protection and environmental interaction. However, studies on cetacean skin microbiomes in the Southern Hemisphere focus on feeding grounds, with limited information on microbiome dynamics at breeding grounds and during migration across contrasting habitats. We characterised the skin microbiome of 46 humpback wha...

This study aimed to synthesize a liposomal nanoformulation containing citrinin (LP-CIT) to improve its availability and to evaluate its toxicogenomic profile, focusing on cytotoxic and genotoxic effects in breast cancer (MDA-MB-231) and non-tumorigenic mammary epithelial (MCF-10A) cell lines. The formulation was characterized by macroscopic appearance, pH, particle size, polydispersity index (PDI), zeta potential, encapsulatio...

Neurodegenerative diseases (NDs) are characterized by progressive neuronal loss associated with excitotoxicity, oxidative stress, neuroinflammation, and impaired neuroplasticity. Fisetin, a naturally occurring flavonoid, has emerged as a potential neuroprotective compound due to its antioxidant and anti-inflammatory properties. In this study, we investigated the effects of fisetin in cellular models of glutamate-induced excito...