Pedro Pinheiro results 118
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The presence of Listeria monocytogenes in food represents a major challenge to food safety, especially in ready-to-eat products stored under refrigeration. This risk is associated with the ability of the pathogen to survive and multiply during prolonged refrigerated storage, making these foods potential sources of infection and a relevant public health concern. In this context, the aim of this study was to investigate the pres...
A mechanistic approach about oxidative, mutagenic, and cytotoxic effects of an organotelluraneNARA Subscribed
Organotellurium (OTe) compounds have pharmacological properties, including leishmanicidal, antimalarial, and antifungal activities. Herein, we assessed cytotoxicity effects of OTe RF07 in a panel of tumor cell lines, as well as its oxidative, toxicity, and hemolytic actions. The toxicity was evaluated on Allium cepa and Artemia salina larvae. Cell viability was also assessed by resazurin in murine cells (Sarcoma 180), human ce...
Development of citrinin-loaded liposomes and in vitro toxicogenetic evaluation on breast cellsNARA Subscribed
This study aimed to synthesize a liposomal nanoformulation containing citrinin (LP-CIT) to improve its availability and to evaluate its toxicogenomic profile, focusing on cytotoxic and genotoxic effects in breast cancer (MDA-MB-231) and non-tumorigenic mammary epithelial (MCF-10A) cell lines. The formulation was characterized by macroscopic appearance, pH, particle size, polydispersity index (PDI), zeta potential, encapsulatio...
Multiform glioblastoma (GBM) is the most aggressive primary brain tumor, associated with high heterogeneity, treatment resistance, and poor survival. Temozolomide (TMZ), although the main chemotherapeutic agent used, shows limited efficacy due to low solubility, chemical instability, and acquired resistance. In this context, nanostructured systems can enhance their antitumor efficacy. This study aimed to develop and characteri...
Optimizing soybean breeding: High-throughput phenotyping for stink bug resistance and high yieldsNARA Subscribed
Background: The stink bug complex is one of the most damaging pests of soybean, reducing yield and seed quality. Genetic resistance remains the most sustainable and effective management strategy, but its quantitative inheritance and labor-intensive field phenotyping make its implementation in breeding programs challenging. Objective: This study explored high-throughput phenotyping (HTP) using unmanned aerial vehicles (UAVs) eq...
Reciprocal effects suggest maternal and extranuclear influences on fruit traits in winter squash breedingNARA Subscribed
Winter squash ( Cucurbita moschata ) seed oil holds significant nutritional and pharmacoeconomic value, yet genetic studies on combining ability and reciprocal cross effects in this species remain scarce. This study assessed genetic variability and estimated general combining ability (GCA), specific combining ability (SCA), reciprocal effects, and gene action for 13 morpho-agronomic traits related to earliness, plant architect...
Understanding the mechanisms underlying fast diversifications is central to evolutionary biology. This can be partly achieved by focusing on intrinsic reproductive barriers that emerge during early stages of divergence in fast‐radiating groups. Here, we explored the mechanisms underlying the divergence of two ecotypes of the Dianthus rupicola complex, which belong to the Eurasian clade of the hyperdiverse genus Dianthus , the...