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Multiplexed targeted mRNA profiling of alcohol-related liver disease reveals stage-specific dysregulation of signaling pathwaysNARA Subscribed
Introduction Alcohol-related liver disease (ALD) remains a leading indication for liver transplantation and a major cause of alcohol-attributable deaths worldwide. The molecular events driving extracellular matrix (ECM) accumulation are incompletely understood. In this study, we aimed to investigate stage-specific gene expression signatures in ALD. Methods and results Liver biopsies from 50 adults with prior alcohol overuse we...
Epileptiform discharges in neurodegenerative diseases linked to atrophy but not associated with iron depositionsNARA Subscribed
Epileptiform discharges in Alzheimer’s disease (AD) and Lewy body dementia (DLB) may be associated with cognitive decline. Iron accumulation has been implicated in neurodegenerative processes; however, its relationship to epileptiform discharges remains unknown. In addition, the relationship between iron deposition, structural brain changes, and epileptiform discharges remains unclear. The objective is to investigate whether i...
Dispersal is one of the most important aspects of animal behavior and can have far‐reaching consequences for organismal ecology and evolution. Despite recent theoretical advances in understanding why individuals within the same population vary in dispersal behavior, relatively few studies have empirically evaluated the long‐term causes and consequences of variable dispersal within natural populations. In this study, we used li...
Can Solar‐Powered Irrigation Systems Naturally Meet Crop Water Requirements? Proof of Concept From a Case Study in Sub‐Saharan AfricaNARA Subscribed
Irrigation scheduling is crucial for ensuring precise water delivery to crops. However, in many sub‐Saharan African irrigation schemes, water is applied without considering crop water needs, resulting in low crop water productivity and low yields. Solar‐powered irrigation systems can automatically meet these needs by utilizing solar radiation, which drives both evapotranspiration and solar panel power production for pumping. T...
Normal cerebral oxygen consumption and lactate levels in patients with Alzheimer’s disease and Lewy body dementiaNARA Subscribed
Brain metabolism is reduced in patients with dementia disorders, as demonstrated by hypometabolism on 2-deoxy-2-[ 18 F]fluoroglucose ([ 18 F]FDG) positron emissions tomography. A contributing factor to the hypometabolism could be decreased cerebral blood flow (CBF) leading to a state of subtle hypoperfusion‐induced tissue hypoxia causing a reduced brain oxygen metabolism and consequently elevated brain lactate. In the current...
Coefficients in Taylor's law increase with the time scale of water clarity measurements in a global suite of lakesNARA Subscribed
Identifying the scaling rules describing ecological patterns across time and space is a central challenge in ecology. Taylor's law of fluctuation scaling, which states that the variance of a population's size or density is proportional to a positive power of the mean size or density, has been widely observed in population dynamics and characterizes variability in multiple scientific domains. However, it is unclear if this phen...
Hepatic encephalopathy as a result of ammonia-induced increase in GABAergic tone with secondary reduced brain energy metabolismNARA Subscribed
Hepatic encephalopathy (HE) is a neuropsychiatric syndrome caused by liver insufficiency and/or portosystemic shunting. HE is mostly episodic and as such reversible. Hyperammonemia clearly plays a key role in the pathophysiology, but the precise detrimental events in the brain leading to HE remain equivocal. Several pathogenic models have been proposed, but few have been linked to clinical studies and observations. Decreased o...
Defining an ageing-related pathology, disease or syndrome: International Consensus StatementNARA Subscribed
Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased health span. With advancing age, the increased prevalence of ageing-related diseases can have a significant impact on health status, functional capacity and quality of life. It is therefore vital to develop comprehensive classification and staging systems for ageing-related pathologies, diseases and syndrom...
Purpose To investigate the impact of soccer training on cardiac adaptations in mildly hypertensive middle-aged women. Methods Hypertensive premenopausal women ( n = 41; age (mean ± SD): 44 ± 7 years; height: 166 ± 6 cm; weight: 78.6 ± 11.6 kg; body fat: 43.3 ± 5.2%) were randomized to soccer training (SOC, n = 21) or control (CON, n = 20). SOC performed three weekly training sessions for 15 weeks, whereas CON had no training o...