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Barriers and facilitators to implementing the European code of cancer practice in a rural and coastal setting: a qualitative studyNARA Subscribed
Purpose The European Code of Cancer Practice (ECCP) is a patient-centred framework for good clinical cancer practice, to improve outcomes for all of Europe’s patients [1]. Given challenges with applications to rural regions, the study aimed to explore the barriers and facilitators to implementing the ECCP in a rural, coastal, and urban context. Methods We conducted semi-structured individual and group interviews with nine acut...
Aging is associated with blood–brain barrier (BBB) breakdown and microvascular rarefaction, key contributors to cerebral neuroinflammation, hypoperfusion, and vascular cognitive impairment and dementia (VCID). Exposure to a young systemic milieu through heterochronic parabiosis has been shown to restore BBB integrity and enhance cerebrovascular function in aged mice, suggesting that circulating factors can rejuvenate the aging...
Lynch syndrome caused by a pathogenic SINE-VNTR-Alu (SVA) insertion in MSH2 gene identified by long-read DNA sequencingNARA Subscribed
Lynch syndrome, the most common hereditary cancer syndrome, is caused by germline pathogenic variants in DNA mismatch repair (MMR) genes. Identifying complex or structural MMR gene pathogenic variants can be challenging with short-read sequencing resulting in patients with unexplained MMR-deficient tumours. In this study, we report multiple members of a family who developed MSH2-deficient tumours where clinical multi-gene pane...
Polar Winter Processes: An Under-Represented Research Focus within the Coupled Earth SystemNARA Subscribed
Observing winter processes during the extended cold season is crucial not only for understanding polar and global coupled Earth system but also for enhancing capability of year-round prediction, especially in the context of Arctic amplification and the drastic decrease in sea ice extent and thickness at both poles. However, harsh environmental conditions and logistical challenges have left polar winter Earth system processes s...
Baleen Whale Occurrence in the Waters Off Virginia and North Carolina, U.S.A. From 2001 to 2019NARA Subscribed
Eighteen years of visual survey and strandings data were used to describe baleen whale occurrence along the continental shelf of Virginia and North Carolina, U.S.A. This region experiences heavy anthropogenic use, which poses risks for mortality and injury to baleen whales. Between 2001 and 2019, six species of baleen whales were recorded, and whales occurred year‐round. The total number of (on‐ and off‐effort) sightings and s...
Marine Isotope Stage 4 glaciation in northern England, UK: Evidence from Victoria Cave, North YorkshireNARA Subscribed
Victoria Cave, north Yorkshire, England, contains a long sequence of Pleistocene clastic sediments and calcite flowstones. Earlier work, using U–Th dating, established that the flowstone units formed in interglacial stages corresponding to Marine Isotope Stages (MIS) 13, 11, 9, 7 and 5. The intervening laminated sediments were therefore assigned to glacial stages (MIS 12, 10, 6 and 2) and regarded as rhythmites that settled fr...