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Using bioinformatics to investigate functional diversity: a case study of MHC diversity in koalasNARA Subscribed
Conservation genomics can greatly improve conservation outcomes of threatened populations, including those impacted by disease. Understanding diversity within immune gene families, including the major histocompatibility complex (MHC) and toll-like receptors (TLR), is important due to the role they play in disease resilience and susceptibility. With recent advancements in sequencing technologies and bioinformatic tools, the cos...
The abyssal seafloor in the Clarion-Clipperton Zone (CCZ) in the NE Pacific hosts the largest abundance of polymetallic nodules in the deep sea and is being targeted as an area for potential deep-sea mining. During nodule mining, seafloor sediment will be brought into suspension by mining equipment, resulting in the formation of sediment plumes, which will affect benthic and pelagic life not naturally adapted to any major sedi...
Disease is a contributing factor to the decline of wildlife populations across the globe. Koalas, iconic yet declining Australian marsupials, are predominantly impacted by two pathogens, Chlamydia and koala retrovirus. Chlamydia is an obligate intracellular bacterium and one of the most widespread sexually transmitted infections in humans worldwide. In koalas, Chlamydia infections can present as asymptomatic or can cause a ran...
Most retroviral endogenization and host adaptation happened in the distant past, with the opportunity to study these processes as they occurred lost to time. An exception exists with the discovery that koala retrovirus (KoRV) has recently begun its endogenization into the koala ( Phascolarctos cinereus ) genome. What makes this opportunity remarkable is the fact that Northern Australian koalas appear to be undergoing endogeniz...
High-throughput immunogenetic typing of koalas suggests possible link between MHC alleles and cancersNARA Subscribed
Characterizing the allelic diversity within major histocompatibility complex (MHC) genes is an important way of determining the potential genetic resilience of a population to infectious and ecological pressures. For the koala ( Phascolarctos cinereus ), endemic diseases, anthropogenic factors and climate change are all placing increased pressure on this vulnerable marsupial. To increase the ability of researchers to study MHC...
Analysis and Conservation Implications of Koala GeneticsNARA Subscribed
Koalas are the only living member of their family and therefore deserve serious conservation consideration. Koalas have low levels of genetic variation within and among populations in the southern part of their range, where they have experienced many relocations and population crashes since European colonization of Australia. The importance of this change in variation is underlined by preliminary indications that levels of gen...
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