Purpose This study assessed two Pb/Zn mining districts in northern Spain using a weight-of-evidence framework based on a reference condition approach integrating three lines of evidence (LOE): sediment chemistry, chronic sediment toxicity, and metal bioaccumulation in field biomonitors. Methods We studied seven sites in Arditurri ( n = 5) and Reocín ( n = 2). In the absence of Spanish sediment quality guidelines, ecological ba...

The freshwater annelid genus Stylodrilus Claparède, 1862 is of great ecological significance due to its broad Holarctic distribution and utility in water quality assessment. While 38 nominal species are currently recognised, molecular analyses suggest the existence of cryptic diversity within the genus. This study primarily focuses on Stylodrilus brachystylus and S. absoloni , whose taxonomic status and phylogenetic relationsh...

Over the last decades, climate change biology has become a central field in global science, yet knowledge production and its inclusion in global strategies remain profoundly unequal. Our bibliometric analysis of over 580,000 records shows that ~80% of author affiliations come from Global North institutions, meaning that research agendas, theoretical frameworks, and priorities are still largely shaped outside the regions with t...

Purpose Quizartinib pharmacokinetics in FLT3-ITD negative acute myeloid leukemia (AML) remain largely unexplored. This study aims to validate a population pharmacokinetics model (popPK) for quizartinib in plasma samples of FLT3-ITD negative AML patients. To do so, an ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) method has been developed and validated for the quantification of quiza...

Guayaquil, Ecuador, is in a tropical area on the equatorial Pacific Ocean coast of South America. Since 2008 the city has been increasing its population, vehicle fleet and manufacturing industries. Within the city there are various industrial and urban land uses sharing the same space. With regard to air quality there is a lack of government information on it. Therefore, the research’s aim was to investigate the spatio-tempora...

The study was performed on residue-effects datasets from polluted and unpolluted sites in the Nalón River basin (northern Spain). The effects were measured in terms of alteration of field macroinvertebrate communities, and measured as ecological status scores, and number of families and abundance of Ephemeroptera, Plecoptera and Trichoptera (EPT). Non-linear regression models of the field-measured tissue residues in 10 taxa re...