The autosomal dominant multisystemic Alagille Syndrome (ALGS) is an important cause of pediatric cholestasis. ALGS is associated with pathogenic variants in JAGGED1 (JAG1) or NOTCH2, ligand and receptor components of the Notch-signaling pathway, respectively. The detected missense variants are commonly classified as variants of uncertain significance, hindering ALGS diagnosis. To overcome this issue, we have developed a CRISPR...

The city of L’Aquila (central Italy) and its surrounding villages have been struck several times throughout history by strong earthquakes, most recently by the $$M_w$$ M w 6.1 event of April 6, 2009. Previously, on February 2, 1703, L’Aquila was partially destroyed by a $$M_w$$ M w 6.7 earthquake, which has remained in the city’s collective memory as the Grande Terremoto (“Big Earthquake”). In this paper, we present a physics-...

The paper presents a comprehensive hydrogeochemical characterization of the volcanic aquifer of the Campi Flegrei caldera (hereafter CFc) (southern Italy). This highly urbanized and restless volcanic area is characterized by recurring bradyseismic phenomena and low- to medium-energy seismicity as well as by anomalous groundwater patterns whose study can be considered an extension of the current volcanic monitoring aimed at haz...

Aim We evaluate the phylogenetic relationships and taxonomic validity of Atlantic species of Labrisomus , identifying the lineages currently assigned to L. nuchipinnis , and assessing the role of biogeographic barriers in shaping the evolutionary history and geographic distribution of the genus. Location Atlantic Ocean. Taxon Labrisomus . Methods We assembled an extensive mitochondrial and nuclear DNA dataset of Atlantic speci...

Many large marine predators forage on mesopelagic fish stocks, including commercially valuable tunas. The mesopelagic is under increasing interest for commercial exploitation, given its large biomass with potential to supply fishmeal for aquaculture feed or fish oil. However, the implications of large‐scale mesopelagic fisheries on tunas and other predators may be substantial. Here, we adapt a bioeconomic model with a new pred...

Modeling species distributions in dynamic pelagic environments remains challenging, particularly for wide‐ranging and highly mobile species when there is limited guidance on model performance. This limitation constrains the effective use of species distribution models (SDMs) in marine conservation, where robust and transferable predictions are essential for conservation planning. Using the loggerhead turtle ( Caretta caretta )...