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Fine-tuning alkyl chain length in copper(II) complexes: effects on DNA binding and catalytic cleavageNARA Subscribed
Metal complexes are well known for their DNA cleavage activity. Copper is a metal that stands out for this purpose because it is able to perform cleavage through oxidative mechanisms using the Haber–Weiss cycle. We report two unprecedented copper(II) complexes ( 2 and 3 ) with long-chain ligands and compare the results with those of a previously reported complex ( 1 ), which we use as a reference in our studies. They were all...
Exploring Ayahuasca Multitarget Potential in Neuropsychiatric Disorders: Integrated Insights Towards Drug DiscoveryNARA Subscribed
Purpose of Review This review integrates evidence from the literature with network pharmacology tools to explore the decoction’s multitarget potential and provide multilevel insights into its therapeutic role in neuropsychiatric disorders. Recent Findings Neuropsychiatric disorders remain a significant health burden, underscoring the limitations of single-target pharmacotherapies and the urgent need for effective multitarget a...
The growing global demand for farmed macroalgae highlights the need to better understand potential contaminant loads, including toxins from harmful algal blooms, and their implications to human health. In this study, the green macroalga Ulva rigida was co-cultivated with the epiphytic dinoflagellate Prorocentrum lima to determine whether toxins produced by the toxic dinoflagellate accumulate in the macroalgae and assess the ef...
Macrourid species constitute the main bycatch in Southern Ocean toothfish longline fisheries. We report the first confirmed record of Whitson's grenadier, Macrourus whitsoni , in the South Georgia toothfish fishery. Mitochondrial cox1 DNA barcoding confirmed its presence in bycatch samples collected around South Georgia and the northern South Sandwich Islands, with approximately 1% divergence from its congener, M. caml . Haplo...
Introduction: Lung cancer remains one of the leading causes of death worldwide, accounting for approximately 1.8 million deaths annually. In this context, low health literacy is frequent and represents a barrier to effective education on screening and early detection. The aim of this study was to translate, culturally adapt, and validate the Lung CAM questionnaire for use in Brazil, enabling the assessment of population litera...
The growing demand for offshore oil and gas production in deep waters has motivated the development of technologies to enable the continuous, reliable, and cost-effective monitoring of subsea equipment. Traditional inspection techniques rely on ROVs and AUVs, leading to delays between data acquisition and recovery and high operational costs. Underwater acoustic communication systems represent an attractive alternative for tran...
Distribution and ecology of the four Macrourus species by‐caught in the longline fishery at South Georgia, Southern OceanNARA Subscribed
Although Macrourus species are the main by‐catch across Southern Ocean longline fisheries, including around South Georgia, the lack of species‐specific data has hindered effective management and ecological understanding. Aggregation of macrourids at genus level masks critical interspecific differences in life‐history strategies and vulnerabilities to fishing. Here, we provide the first comprehensive biological assessment of th...
Stability Specifications for Climate Data Records: Their Meaning and Application in Evaluating Geophysical Trend UncertaintyNARA Subscribed
When quantifying changes over time in the natural environment, the stability of the observations used should be considered. Stability conceptually refers to how accurately true geophysical changes and trends are reflected in observational data. We argue the need for a better approach to defining and quantifying stability consistently across climate data records. We propose that the appropriate stability metric is the stability...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
Purpose of Review Forest ecosystem multifunctionality, the capacity of forests to simultaneously deliver multiple ecosystem functions and services, is being increasingly affected by pressures stemming from anthropogenic activities and climate change. Here, we conducted a systematic literature review to explore how forest ecosystem multifunctionality was evaluated in the literature, and to identify its main drivers. Recent Find...