Three new isatin–pyridine-2-oxime hybrids (AM01–03) were synthesized and experimentally evaluated as reactivators of acetylcholinesterase (AChE) inhibited by a surrogate of the nerve agent A-242, in comparison with their 4-oxime isomers previously reported by our research group. Furthermore, the interactions of these molecules within the AChE/A-242 complex were assessed through docking and molecular dynamics (MD) simulations....

Aim We investigate the distribution of dispersal modes — endozoochory (via animal ingestion), synzoochory (via animal seed accumulation) and anemochory (via wind)—and seed mass of woody plants across Brazilian ecosystems, testing whether their relative abundance in local plant communities could be predicted by climate, edaphic factors and dispersal agents (e.g., the main vectors moving seeds). We expected climate to be the mai...

Background Despite advanced analytical methods and increasing data availability, most intensive care unit (ICU) prediction models rely on static measurements. However, longitudinal monitoring of biomarkers may better capture disease progression and support timely, individualized interventions within the framework of predictive, preventive, and personalized medicine (PPPM). Since the COVID-19 pandemic, interest in both static a...

Aim We investigated how local‐scale environmental heterogeneity influences biodiversity patterns across broad biogeographic gradients, using intertidal microhabitats as a model system within one of the most environmentally stressful ecosystems on Earth. Location Intertidal habitats at 26 locations (two rocky shore sites per location) across six continents, spanning 98° of latitude (38°S to 60°N). Time Period 2019–2022. Major T...

In recent years, there has been an increasing need for climate information across diverse sectors of society. This demand has arisen from the necessity to adapt to and mitigate the impacts of climate variability and change. Likewise, this period has seen a significant increase in our understanding of the physical processes and mechanisms that drive precipitation and its variability across different regions of Africa. By levera...

The COVID-19 pandemic triggered unparalleled political, economic, and social ramifications, exacerbating global food insecurity (FI). To understand the overall impact of the pandemic and how different socio-economic groups were affected, we assessed prevalence and severity of FI in a sample of 18,997 households across seven countries in South America. We employed the Food Insecurity Experience Scale developed by the FAO. Our r...

This review article provides a synthesis and perspective on how weather and climate extreme events can play a role in influencing tipping elements and triggering tipping points in the Earth System. An example of a potential critical global tipping point, induced by climate extremes in an increasingly warmer climate, is Amazon rainforest dieback that could be driven by regional increases in droughts and exacerbated by fires, in...