R.D. Moore results 193
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The future of how we understand and manage ecosystems largely depends on direct and continuous observations that connect local territories to planetary processes. Latin America (LATAM: Mexico, Central and South America, and the Caribbean) hosts ecosystems critical for regulating global carbon, water, and energy cycles. However, persistent underinvestment in science and technology hampers the long‐term monitoring capacity neede...
Fentanyl decreases arterial blood oxygen saturation more than furanylfentanyl in mice due to increased apneaNARA Subscribed
Rationale Fatal opioid overdoses involving synthetic opioids have increased >10-fold over the past 8 years. Fentanyl, a potent synthetic opioid acting at the mu-opioid receptor (MOR), has largely replaced heroin as the predominant illicit opioid available. Various analogs have been synthesized from the fentanyl scaffold, including 2-furanylfentanyl, one of the most trafficked analogs from 2019 to 2024. Despite its prevalence,...
Population Genomics of a Cosmopolitan Weed Provides Insights Into Its Local Adaptation and Recent Demographic HistoryNARA Subscribed
Invasive plant species present a growing ecological and economic challenge, and often adapt rapidly to their novel environments through complex demographic and evolutionary processes. Invasion genomics offers powerful tools to disentangle these processes, but most studies rely on geographically narrow sampling across native and non‐native ranges. Erigeron canadensis is a cosmopolitan weed native to North America that has succe...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
With over half of people with HIV (PWH) in the U.S. entering older adulthood, identifying markers to distinguish Alzheimer’s disease (AD) and its precursor, amnestic mild cognitive impairment (aMCI), from other forms of neurocognitive impairment among PWH is urgent. We examined how HIV and aMCI status relate to AD CSF biomarkers in adult PWH and people without HIV (PWoH) characterized for aMCI. We included 80 PWH from the Nati...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Micro‐Refuges or Ecological Traps: Context‐Dependent Effects of Rock Pools on Intertidal Biodiversity Across LatitudesNARA Subscribed
Aim We investigated how local‐scale environmental heterogeneity influences biodiversity patterns across broad biogeographic gradients, using intertidal microhabitats as a model system within one of the most environmentally stressful ecosystems on Earth. Location Intertidal habitats at 26 locations (two rocky shore sites per location) across six continents, spanning 98° of latitude (38°S to 60°N). Time Period 2019–2022. Major T...
Spatiotemporal Patterns and Drivers of Fish Biodiversity on a Remote Freshwater ArchipelagoNARA Subscribed
Aim Fish communities are shaped by environmental filters operating across different spatiotemporal scales. While many recent studies focus on anthropogenic gradients, few can isolate the role of natural drivers in community assembly. Isle Royale's inland lakes offer a rare opportunity to explore long‐term fish biodiversity dynamics with minimal confounding influences. We analysed fish communities in 23 lakes surveyed in the 19...
BMP9 knockout impairs pulmonary vessel muscularisation and confers aberrant tamoxifen sensitivityNARA Subscribed
Deleterious mutations in the GDF2 gene, encoding BMP9, are causative of pulmonary arterial hypertension and hereditary haemorrhagic telangiectasia. Paradoxically, BMP9 germ-line knockout ( Gdf2 −/− ; Bmp9 KO) and double Bmp9 KO / conditional Bmp10 cKO (dKO) mice exhibit an attenuated response to PAH-inducing stimuli. We asked whether this contradiction is due to the pathological, physiological, or genetic consequences of BMP9...
Several legal acts mandate that management agencies regularly assess biological populations. For species with distinct markings, these assessments can be conducted noninvasively via capture‐recapture and photographic identification (photo‐ID), which involves processing considerable quantities of photographic data. To ease this burden, agencies increasingly rely on automated identification (ID) algorithms. Identification algori...
Nutrient limitation dampens the response of a harmful algae to a marine heatwave in an upwelling systemNARA Subscribed
Harmful algal blooms caused by toxin‐producing species of the diatom genus Pseudo‐nitzschia have been linked to anomalously warm ocean conditions in the Northern California Current System. This study compares summertime concentrations of Pseudo‐nitzschia spp. and the toxin they produce, domoic acid, during a marine heatwave year (2019) and a climatologically neutral year (2021). An Imaging FlowCytobot was installed on a fisher...
The Seaward Migration of European Eel at a Continental Scale: A Europe‐Wide Biotelemetry Meta‐AnalysisNARA Subscribed
The European eel ( Anguilla anguilla L.) has a catadromous life cycle, with a single panmictic population that colonises continental Europe and northern Africa yet migrates 5000 to 9000 km to spawn in the Atlantic Ocean. It is unknown how this continental migration is organised so individual eels arrive in time for spawning with conspecifics. This meta‐analysis combined tracking data from 18 water bodies in freshwater and tran...
Global Change Asymmetrically Rewires EcosystemsNARA Subscribed
Global change is complex and multidimensional, making it challenging to understand how human activities affect ecosystem processes. A critical gap in this understanding is how drivers of global change broadly affect food webs. While an industry of studies documents shifts in food webs in response to anthropogenic pressures, a general synthesis is lacking. To address this, we review studies across diverse ecosystems that use st...