Are there limits to our ability to adapt food systems to climate change? This overview paper for the special issue highlights results of research on potential limits and responses by food system actors. Responses are shaped by the critical interactions among the physical, chemical, biological, and social impacts in food systems arising from climate change. Food grains, temperate perennials, livestock, and oceanic capture fishe...

Climate change scenarios have significant implications for the livelihoods and food security of particular groups in society and will necessitate a range of adaptation actions. While there is a significant literature on the social as well as biophysical factors and limits to adaptation, less is known about the interactions between these, and what such interactions mean for the prospects of achieving sustainable and resilient f...

Pathogenic germline exonuclease domain (ED) variants of POLE and POLD1 cause the Mendelian dominant condition polymerase proof-reading associated polyposis (PPAP). We aimed to describe the clinical features of all PPAP patients with probably pathogenic variants. We identified patients with a variants mapping to the EDs of POLE or POLD1 from cancer genetics clinics, a colorectal cancer (CRC) clinical trial, and systematic revie...

Coral reefs are declining globally as climate change and local water quality press environmental conditions beyond the physiological tolerances of holobionts—the collective of the host and its microbial symbionts. To assess the relationship between symbiont composition and holobiont stress tolerance, community diversity metrics were quantified for dinoflagellate endosymbionts (Family: Symbiodiniaceae) from eight Acropora mille...