Sharm El-Luli, one of the most pristine embayments along Egypt’s Red Sea coast, is increasingly recognized as a sensitive sink for terrigenous inputs and emerging anthropogenic pressures. This study assesses the distribution, sources, and ecological and human health implications of heavy metals in bottom sediments collected throughout the lagoon. Concentrations of Fe, Mn, Zn, Cu, Pb, Ni, Cd, and Co were quantified and assessed...

Lorundrostat, a novel selective aldosterone synthase inhibitor, has emerged as a potential treatment for uncontrolled hypertension. However, a comprehensive summary of its efficacy and safety profile is currently lacking. This meta-analysis aims to synthesize evidence from published randomized controlled trials (RCTs) to evaluate the clinical benefits and risks of lorundrostat in this patient population. Following the PRISMA g...

Cyclophosphamide (CP) is an anti-cancer medication that also treats chronic inflammatory illnesses caused by the immune system. Although CP is widely used, it can occasionally have limited therapeutic efficacy due to its significant combined toxicities. Ovarian damage caused by CP is a major problem for patients, and premature ovarian failure (POF) is a serious side effect of CP that commonly affects female patients. Mechanist...

Pomegranate peel extract is rich in total phenolics with high antioxidant activity. Furthermore, prolonging the laying period of hens is a growing trend that offers both financial and environmental benefits. Therefore, the current study aimed to investigate the potential effects of Pomegranate peel powder extract (PPPE) on aged laying chickens. One hundred twelve ISA White chickens, 80 weeks old, were randomly distributed into...

Psoriasis is a chronic, immune-mediated inflammatory disorder that significantly impacts patients’ quality of life. Oral systemic therapies, including methotrexate, cyclosporine, acitretin, and apremilast, remain integral to psoriasis management, particularly for patients with moderate-to-severe disease who cannot afford biologic therapy. While these treatments are effective, their long-term use is often limited by adverse eff...

Hyalomma dromedarii ( H. dromedarii ) is a major ectoparasite of camels in arid regions such as Egypt, where it causes significant economic losses and transmits several zoonotic pathogens. This study evaluated the acaricidal efficacy of a novel, locally prepared Astragalus polysaccharides nanoemulsified formulation (APS-NE) against various developmental stages of H. dromedarii infesting camels. APS-NE was prepared using ultras...

Twenty-nine sediment samples were collected from Hurghada Bay, a highly impacted coastal area along the Northern Red Sea of Egypt, to evaluate environmental quality and human-induced effects on benthic ostracods. As potential bioindicators, benthic ostracods are highly responsive to environmental disturbances, with pollution leading to reduced abundance, lower diversity, and increased opportunistic taxa. To investigate the lin...

Genetic causes of steroid-resistant-nephrotic-syndrome (SRNS) represent a rapidly growing number of monogenic diseases. The reported diagnostic yield of various studies applying genetic panels and exome-sequencing to diagnose SRNS is usually < 30%. We performed genome-sequencing in a cohort of Egyptian SRNS patients. We recruited 47 SRNS patients belonging to 41 unrelated families [28 males/19 females; median (range): 6 (0.5–2...

The middle–upper Eocene successions of northwest Fayum, Egypt, provide a crucial archive for reconstructing paleoenvironmental conditions and paleobiogeographical patterns of the southern Tethys realm. Stratigraphically, the investigated section is subdivided into three rock units: the Gehannam Formation (Bartonian-Priabonian), the Birket Qarun Formation, and the Qasr El Sagha Formation (Priabonian). A total of 101 benthic for...