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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Rationale Between periods of use, chronic cannabis consumers may display residual effects on selective cognitive functions, particularly memory and attention. Whether there are comparable deficits in real-world behaviors, such as driving, has not been thoroughly examined. Objectives The current study explored the association between driving simulator performance, cannabis use history, and demographic factors after ≥ 48 h of ab...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Operational principles for fostering transformative qualities and capacities in higher education sustainability science and practiceNARA Subscribed
Education for sustainability is widely recognised as a critical pathway for driving the transformations needed to address today’s polycrisis. Despite growing theoretical and conceptual advancements in sustainability education, current approaches have not achieved the deep systemic changes required. While university networks and individual institutions increasingly integrate sustainability into their education, concerns persist...
A fundamental trade‐off among resilience, resistance, efficiency, and redundancy in tidal wetlandsNARA Subscribed
In an era of change, the survival and adaptability of ecosystems will be tested. An optimal ecosystem would be both resistant and resilient to negative disturbance but also efficient and redundant in its growth when given positive subsidies. However, initial evidence has suggested that these properties cannot all be maximized at the same time, and so we sought to quantitatively assess whether there are fundamental trade‐offs b...
Congener Conflict: Invasive Barred Owl Landscape Use Across the Range of the Northern Spotted OwlNARA Subscribed
Aim To map the probability of landscape use of invading barred owls ( Strix varia ) across the range of the threatened northern spotted owl ( S. Occidentallis Caurina ) in the Pacific Northwest, USA , identifying environmental drivers of barred owl landscape use to inform targeted management interventions. Location Forests of the Pacific Northwest, USA. Taxon Barred Owl ( Strix varia ). Methods We deployed 4081 autonomous reco...
The Nature Futures Framework (NFF) aims to open up space for plural perspectives on human–nature relationships and to identify visions for people to navigate towards desirable nature-positive futures. Operationalising the NFF offers a way to explore alternative pathways to reach these futures, but such applications are currently underdeveloped. Normative narratives can describe pathways towards nature-positive futures based on...