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Adverse childhood experiences, adult adiposity, and risk of young-onset breast cancer subtypes in a population-based case-control studyNARA Subscribed
Purpose Adverse childhood experiences (ACEs) are hypothesized to increase breast cancer risk via social and physiological pathways, yet associations between ACEs and young-onset breast cancer (BC) subtypes–and potential mediators (e.g., adiposity) of these associations–are largely unstudied. We sought to evaluate associations between ACEs and young-onset BC molecular subtypes, and the potential mediating effects of adiposity,...
Evaluating past and future contributions of conservation programs to species recoveryNARA Subscribed
Impact evaluation of conservation actions is a crucial step in global efforts to curb the biodiversity crisis. Through robust impact evaluation, practitioners can assess the effectiveness of conservation strategies and optimize the use of limited resources. Despite a proliferation of methods and tools for evaluating conservation impact, no standardized method exists to assess and compare the impact, and global contribution, of...
Genomics‐Driven Monitoring of Fraxinus latifolia (Oregon Ash) to Inform Conservation and EAB ‐Resistance BreedingNARA Subscribed
Understanding the evolutionary processes underlying range‐wide genomic variation is critical to designing effective conservation and restoration strategies. Evaluating the influence of connectivity, demographic change and environmental adaptation for threatened species can be invaluable to proactive conservation of evolutionary potential. In this study, we assessed genomic variation across the range of Fraxinus latifolia , a f...
Neuromusculoskeletal Modeling and Force Prediction: Verification Through Experimental Neuromuscular DynamicsNARA Subscribed
Purpose Neuromusculoskeletal (NMS) function is influenced by the interactions between neural and musculoskeletal systems. Age-related changes in motor unit morphology contribute to changes in motor control and force production with advancing age; however, a better understanding of the underlying mechanisms between force production and motor unit reorganization and their interrelationships is needed to develop targeted therapie...
Horse mussels (Modiolus modiolus) create complex beds (aka reefs) that provide a range of vital ecosystem services. Unfortunately, these ecologically significant habitats are highly sensitive to human activity and are very slow to regenerate (if at all). As an example, there are cases in the Irish Sea and Strangford Lough where extensive beds have been severely declined or destroyed by fishing activity. Whilst individuals are...
Conservation benefits of a large marine protected area network that spans multiple ecosystemsNARA Subscribed
Marine protected areas (MPAs) are widely implemented tools for long‐term ocean conservation and resource management. Assessments of MPA performance have largely focused on specific ecosystems individually and have rarely evaluated performance across multiple ecosystems either in an individual MPA or across an MPA network. We evaluated the conservation performance of 59 MPAs in California's large MPA network, which encompasses...
Purpose The EU Water Framework Directive (European Union Off J Eur Comm 2000) and EU Waste Framework Directive (European Union Off J Euro Union 2008) impacted the Beneficial Use (BU) of sediments in Europe. INTERREG has supported initiatives to change the perception that sediments are a waste. In this paper we provide an overview of tools, pilot sites and measuring techniques developed and used for the BU of sediments within s...
Dispersal patterns of sandfish (Holothuria scabra) larvae in Manus Province, Papua New GuineaOA Marine
In many tropical nations, coastal communities seek to manage their sea cucumber fisheries by establishing locally managed marine areas on their traditional fishing grounds. These managed areas can protect spawning stocks, however the extent to which they help to replenish nearby sea cucumber fisheries is debated, as nothing is known about the scales at which sea cucumber larvae disperse. In this study, we used genetic parentag...
Collaborative fisheries research programs engage stakeholders in data collection efforts, often with the benefit of increasing transparency about the status and management of natural resources. These programs are particularly important in marine systems, where management of recreational and commercial fisheries have historically been contentious. One such program is the California Collaborative Fisheries Research Program (CCFR...
A marine protected area network does not confer community structure resilience to a marine heatwave across coastal ecosystemsNARA Subscribed
Marine protected areas (MPAs) have gained attention as a conservation tool for enhancing ecosystem resilience to climate change. However, empirical evidence explicitly linking MPAs to enhanced ecological resilience is limited and mixed. To better understand whether MPAs can buffer climate impacts, we tested the resistance and recovery of marine communities to the 2014–2016 Northeast Pacific heatwave in the largest scientifical...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Global co‐occurrence of methanogenic archaea and methanotrophic bacteria in Microcystis aggregatesNARA Subscribed
Summary Global warming and eutrophication contribute to the worldwide increase in cyanobacterial blooms, and the level of cyanobacterial biomass is strongly associated with rises in methane emissions from surface lake waters. Hence, methane‐metabolizing microorganisms may be important for modulating carbon flow in cyanobacterial blooms. Here, we surveyed methanogenic and methanotrophic communities associated with floating Micr...
Purpose The etiology of young-onset breast cancer (BC) is poorly understood, despite its greater likelihood of being hormone receptor-negative with a worse prognosis and persistent racial and socioeconomic inequities. We conducted a population-based case–control study of BC among young Black and White women and here discuss the theory that informed our study, exposures collected, study methods, and operational results. Methods...
The global Microcystis interactomeNARA Subscribed
Bacteria play key roles in the function and diversity of aquatic systems, but aside from study of specific bloom systems, little is known about the diversity or biogeography of bacteria associated with harmful cyanobacterial blooms (cyanoHABs). CyanoHAB species are known to shape bacterial community composition and to rely on functions provided by the associated bacteria, leading to the hypothesized cyanoHAB interactome, a coe...