Sporotrichosis is a globally distributed subcutaneous mycosis caused by fungi belonging to the Sporothrix genus. The limitations of current treatment options for sporotrichosis have driven an urgent search for new antifungal drugs. Diphenyl diselenide (PhSe)₂, a stable organoselenium, has promising activity against Sporothrix spp. Since chemical modifications in molecules can enhance their antifungal properties, this study aim...

Understanding individual growth is essential for assessing exploitation status and supporting sustainable fishery management. For the southern Brazilian stock of the mullet Mugil liza, previous growth estimates were based on whole otolith readings and included few young individuals, potentially influencing growth parameter estimation and stock assessment outputs. In this study, daily otolith microincrements of juveniles were v...

Background Benign prostatic hyperplasia (BPH) is a highly prevalent condition among aging men and a major cause of lower urinary tract symptoms (LUTS). Although α1-adrenoceptor blockers and 5-alpha-reductase inhibitors remain the cornerstone of treatment, their long-term use is frequently limited by adverse effects and suboptimal symptom control. Growing experimental and clinical evidence suggests that chronic prostatic inflam...

Lepidocybium flavobrunneum [Smith, 1843], commonly known as escolar, is a large pelagic species, important for global and local fisheries, particularly in the southwestern South Atlantic Ocean (SWAO), where it constitutes a significant portion of the catch. However, despite its important socioeconomic role, it remains less studied compared to other large pelagic species. Enhancing research efforts is therefore key to better un...

This article presents an analysis of regulatory compliance in a Brazilian gillnet fishery, based on Vessel Monitoring System ( VMS ) tracking data. Satellite transmissions records, interpreted as proxies for gillnet haulings events, were analyzed and classified using a neural network to assess the level of compliance of the gillnet fleet. Four key regulatory criteria assessed: (i) satellite tracking rules; (ii) net length; (ii...

Anthropogenic marine disasters impair biodiversity, ecosystem services provisioning, and socioeconomic development, with long-lasting consequences. Robust impact assessment, however, depends on understanding the spatiotemporal variability of the indicators used to detect change. Here, we present the results of a monitoring program (2018–2025) targeted at two Coastal and Marine Protected Areas located 40 km south of the Doce Ri...

Life‐history data are often lacking for exploited elasmobranchs, jeopardizing proper management and conservation measures for this vulnerable group. Herein, we provided age and growth estimates for the groovebelly stingray ( Dasyatis hypostigma ), a medium‐sized, heavily exploited batoid endemic to the southwestern Atlantic Ocean. Ages were estimated from vertebral centra, including 201 males and 71 females, with sizes varying...

The metabolism of tumor cells exerts a great influence on the tumor microenvironment (TME) of solid tumors and antitumor immune responses. Targeting molecules from the TME is an exciting strategy to overcome the ability of solid tumors to escape immunity and immunotherapies. In this sense, this manuscript delves into the complex and sometimes antagonizing role of amino acids in the TME, regulating both tumor cells and immune c...

Kelp forests are experiencing extreme declines globally, yet local social-ecological factors may mediate their responses to climate perturbations. Using a combination of long-term field surveys (2016–2023) and satellite data (2004–2023), we examined the regional effects of the 2014–2016 marine heatwaves regime on kelp forest ecosystems along a 600 km latitudinal gradient in Baja California, Mexico. We documented three distinct...

Fluoride is commonly used in dentistry to prevent dental caries, however, excessive exposure may pose risks to soft tissues, particularly the kidneys, which are responsible for approximately 60% of fluoride excretion. Diabetic nephropathy, a major complication of diabetes mellitus, may share pathogenic pathways with fluoride-induced renal toxicity. However, the combined effects of chronic hyperglycemia and fluoride exposure on...

Although some effects of glucocorticoids are necessary for metabolic responses during stress, chronic exposure to high levels of these hormones can cause side effects such as hyperglycemia, insulin resistance, and muscle atrophy. Elevated glucocorticoid levels are observed in several clinical conditions, and their exogenous administration, such as high-dose dexamethasone treatments, is included in many clinical protocols. In t...