Rui Lopes results 106
· Newest (Page 1/5, per page 25)
Author: Rui Lopes ×Clear All Filters
Search Results
The impact of genetic variants of the IGF-1 axis on surgical outcomes and prognosis in ovarian cancerNARA Subscribed
Background Ovarian cancer (OC) remains the most lethal gynaecological malignancy, largely due to late-stage diagnosis, tumour heterogeneity, and high recurrence rates. The insulin-like growth factor-1 (IGF-1) axis has been implicated in tumour proliferation, survival, and treatment resistance. Yet, the prognostic relevance of its genetic variants in OC is not well established. The present study aims to evaluate the impact of t...
Purpose The European Medicines Agency (EMA) guideline Declaration of Storage Conditions in the Product Information of Medicinal Products (CPMP/QWP/609/96/Rev.2) was last revised in 2007. Since then, advances in stability science, increased climatic variability, and evolving regulatory expectations have highlighted limitations in the framework, particularly the use of vague descriptors such as “room temperature” or “no special...
Air pollution remains a persistent environmental and public health concern in urban regions. This study presents a 22-year analysis (2001–2022) of coarse particulate matter (PM 10 ) concentrations across 15 monitoring stations in the Porto Metropolitan Area (PMA), Portugal. The stations, pre-classified by national authorities as traffic, background-urban, background-suburban, or industrial, were used to assess long-term tempor...
A summary of the Lucy Ashton resistance prediction workshopNARA Subscribed
Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R packag...
Worldwide, many coastal freshwater ecosystems suffer from seawater intrusion. In addition to this stressor, it is likely that the biota inhabiting these ecosystems will also need to deal with climate change-related temperature fluctuations. The resilience of populations to long-term exposure to these stressors will depend on their genetic diversity, a key for their adaptation to changing environments. Accordingly, this study a...