Understanding the links between metabolism, ageing, and age-related phenotypes may clarify the role of ageing in disease onset and improve risk prediction. We conducted a cross-cohort assessment of biological age using broad-spectrum LC–MS metabolomics of 3,686 plasma samples in 2,295 participants, aged 20–89, from the UK Airwave study ( N = 960) and the Irish Longitudinal Study of Ageing ( N = 1,335). The nucleoside N 2 ,N 2...

Aligned with the Green Deal strategy to reduce the impacts of climate change on the agri-food sector, this study assessed the potential of a commercial biostimulant based on Ascophyllum nodosum extract to improve olive tolerance to drought. Potted plants of Olea europaea (cultivars Arbequina and Galega) were pre-treated with the extract or water. One group was maintained at 100% field capacity and another under water-deficit (...

WHO ranked chronic inflammatory diseases as the most significant cause of death. The current therapeutic approach is the constant administration of clinically available anti-inflammatory drugs; however, this strategy presents severe side effects. New entities derived from plants have shown their potential for developing safe and effective therapies. Particularly, Echinacea purpurea extracts have demonstrated strong anti-inflam...

In the northeast region of Brazil, melon production has been affected by root diseases caused by Macrophomina species. This study aimed to analyse the influence of inoculation methods using three Macrophomina species ( M. phaseolina , M. pseudophaseolina , and M. euphorbiicola ) on the expression of symptoms of root rot and branch decline in melon plants. Two inoculation methods were evaluated in greenhouse experiments: (1) in...

Aim We investigated how local‐scale environmental heterogeneity influences biodiversity patterns across broad biogeographic gradients, using intertidal microhabitats as a model system within one of the most environmentally stressful ecosystems on Earth. Location Intertidal habitats at 26 locations (two rocky shore sites per location) across six continents, spanning 98° of latitude (38°S to 60°N). Time Period 2019–2022. Major T...

Familial hypercholesterolemia, caused by mutations in the low-density lipoprotein receptor (LDLr), is associated with cognitive and affective disturbances. However, sex differences in the impact of LDLr deficiency on anxiety and social behaviors remain poorly characterized. Male and female LDLr⁻/⁻ and wild-type (WT) C57BL/6 mice (4–5 months old) underwent a battery of behavioral tests assessing locomotion, anxiety-like behavio...

The whiteleg shrimp, Penaeus vannamei , is a highly valued and globally produced crustacean species. However, the rising cost of shrimp feed, exacerbated by increasing cereal prices, prompts the exploration of cost-effective and sustainable formulations. This study investigates the potential of Salicornia ramosissima biomass by-product (the non-edible part) as a substitute for wheat meal in juvenile shrimp diets, aiming to cre...

Sustainability is becoming increasingly relevant due to the need to decide on planned management of land use and natural resources as well as sustainable development in the context of cities. This study aims to identify indicators for measuring the sustainable development of districts/countries in Bulgaria. Using the Multivariate Analysis (MVA) method, where we examine multiple variables in several dimensions, the results show...

Fire blight disease, caused by Erwinia amylovora is present worldwide and affects over 40 countries in Europe where it is listed as a quarantine or regulated pest often due to ineffective control strategies maladapted to the respective production systems. In Portugal, the disease was confirmed in 2010 and the occurrence of disease outbreaks in new production areas has risen over the years. The disease affects the national prod...

The health benefits of exercise training in a cancer setting are increasingly acknowledged; however, the underlying molecular mechanisms remain poorly understood. It has been suggested that extracellular vesicles (EVs) released from contracting skeletal muscles play a key role in mediating the systemic benefits of exercise by transporting bioactive molecules, including myokines. Nevertheless, skeletal muscle-derived vesicles a...

The persistence and progression of Erwinia amylovora in naturally infected orchards is still not fully understood and the majority of studies have been carried out under controlled or artificial infections. A major hurdle stems from the inability to characterize the viability of the bacterium in its natural state. Most standard tests, including real-time qPCR, fail to differentiate live from dead cells, while culture dependent...