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Identifying the proton donor in electrocatalytic hydrogen evolution by a model hydrogenaseNARA Subscribed
Proton transfer is essential in all multi-electron transformations. Identifying the proton donor in such processes is crucial to understanding the catalytic mechanism and optimizing activity through pK a matching, which can enhance proton transfer rates. However, aqueous solutions offer multiple proton sources, which confounds clear identification of the catalytically relevant proton donor. In this work, we utilize a model hyd...
The future of how we understand and manage ecosystems largely depends on direct and continuous observations that connect local territories to planetary processes. Latin America (LATAM: Mexico, Central and South America, and the Caribbean) hosts ecosystems critical for regulating global carbon, water, and energy cycles. However, persistent underinvestment in science and technology hampers the long‐term monitoring capacity neede...
An experimental approach to assess the combined effects of multiple stressors on a large vertebrate speciesNARA Subscribed
The design of experiments to investigate the combined effects of multiple stressors requires exposing target organisms to multiple combinations of stressor doses. Concurrent manipulation of stressors is often infeasible with wildlife, but long‐lasting health effects allow individual health to be used as an integrator of prior stressor exposure. The population of bottlenose dolphins in Barataria Bay, Louisiana, experienced long...
Fentanyl decreases arterial blood oxygen saturation more than furanylfentanyl in mice due to increased apneaNARA Subscribed
Rationale Fatal opioid overdoses involving synthetic opioids have increased >10-fold over the past 8 years. Fentanyl, a potent synthetic opioid acting at the mu-opioid receptor (MOR), has largely replaced heroin as the predominant illicit opioid available. Various analogs have been synthesized from the fentanyl scaffold, including 2-furanylfentanyl, one of the most trafficked analogs from 2019 to 2024. Despite its prevalence,...
Purpose of Review Radiotherapy serves as a palliative option for alleviating cancer pain but can also elicit chest wall pain following stereotactic body radiotherapy (SBRT). The etiology of chest wall pain remains unclear but may relate to SBRT effects on normal ribs and responses from activated osteoclasts. This review explores potential mechanisms and treatment strategies for this increasingly common complication for patient...
Global patterns and regional insights into kelp forest protection, restoration, and stewardshipNARA Subscribed
Kelp forests are among the most extensive and productive coastal ecosystems, yet they remain underrepresented in global conservation policy despite widespread declines driven by interacting global- (i.e., ocean warming, marine heatwaves) to local-scale stressors. At the same time, kelp conservation and restoration efforts are expanding rapidly across regions, but measures of success and syntheses tend to primarily focus on eco...
The Integration of Fire Ecology and Freshwater Ecosystems in North America: Knowledge Gaps and Research NeedsNARA Subscribed
Wildfires, unplanned fires that start and spread under the influence of weather and fuel composition, are increasing in frequency, duration, and severity across North America. While wildfires are one component of wildland fire, a broader natural process in many ecosystems, their changing behavior poses growing ecological and management challenges. Although wildfire is widely recognized as an important disturbance, empirical re...
Ataxia disorders have complex symptomology and few treatment options. Limited information is available on symptoms and quality of life with ataxia from the perspective of patients and caregivers. We aimed to assess whether trends in symptoms and quality of life varied by ataxia type and disease stage. We conducted an anonymous, international survey of 680 National Ataxia Foundation Members, including 587 people with ataxia and...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Success of restoration strategies in preventing extirpation of 2 critically endangered coral speciesNARA Subscribed
An unprecedented marine heatwave in 2023 caused widespread coral bleaching and mortality throughout the Caribbean. In the Florida Keys (USA), 2 foundation species, elkhorn coral ( Acropora palmata ) and staghorn coral ( Acropora cervicornis ), were severely affected. These species have been the primary focus of reef restoration in Florida for decades. Substantial losses of these species occurred in outplanted populations, in o...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
The interactive effects of nitrate and road salt on benthic algal assemblages in an artificial stream experimentNARA Subscribed
Urban surface water runoff contains high levels of salt and nitrate, particularly in northern climates of the USA. We hypothesized that increased salt and nitrate concentrations would reduce total biomass and cause complete taxonomic shifts of benthic algae. To investigate and quantify the multi-tiered responses of benthic algal assemblages to the impacts of road salt and nitrate, we created artificial flow-through streams wit...
Micro‐Refuges or Ecological Traps: Context‐Dependent Effects of Rock Pools on Intertidal Biodiversity Across LatitudesNARA Subscribed
Aim We investigated how local‐scale environmental heterogeneity influences biodiversity patterns across broad biogeographic gradients, using intertidal microhabitats as a model system within one of the most environmentally stressful ecosystems on Earth. Location Intertidal habitats at 26 locations (two rocky shore sites per location) across six continents, spanning 98° of latitude (38°S to 60°N). Time Period 2019–2022. Major T...