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High Site Fidelity and Elevated δ¹⁵N in Bonefish (Albula vulpes) Suggest Localized Wastewater Stress in a Marine National ParkNARA Subscribed
Coastal zones are subjected to many anthropogenic stresses that operate on multiple spatial scales. Understanding how these stressors interact with the movement and resource ecology of mobile species is critical for effective conservation and management. Biscayne National Park (BNP) is adjacent to Miami (U.S.) and supports an economically important recreational fishery for bonefish ( Albula vulpes ). Within BNP, the western re...
Purpose Exercise can reduce C-reactive protein (CRP), but heterogeneity exists and it is unclear whether exercise-induced weight compensation occurs or relates to CRP change. We examined whether compensation occurs in adults with elevated CRP during exercise and whether compensation and compensatory behaviours are associated with CRP change. Methods In this 4-month randomised controlled trial, 124 sedentary adults with elevate...
The fast‐slow continuum is a key axis of variation in life history strategies capturing the evolutionary trade‐off between allocation in lifespan versus reproduction. It has been suggested that social behaviour, and therefore network structure, may vary across this continuum, but formal theory remains scarce. We develop a mathematical model to examine how the rate of demographic replacement may influence emergent social networ...
Purinergic modulation of neurotransmission is a primary strategy employed in rapid neuroprotection during and after ischemic stroke. While the contributions of adenosine and ATP to the purinome are well-documented, guanosine-based regulatory activity has remained under-investigated. In the ischemia-vulnerable CA1 region of the hippocampus, dopamine serves as both a neurotransmitter involved in long-term potentiation during mem...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...