Brazil is a country with an approximate 50% prevalence rate of carbapenem-resistant Pseudomonas aeruginosa (CR-PA). Therefore, monitoring the spread of high-risk clones from complex genotypes of CR-PA isolates is crucial for developing effective strategies to control antimicrobial resistance. In the present study, we aimed to evaluate the dissemination of high-risk clones P. aeruginosa carrying bla KPC-2 in Brazil. In this stu...

Increasing life expectancy has been accompanied by a higher prevalence of age-associated conditions, underscoring the need to better understand biological mechanisms of aging and to identify accessible biomarkers. Extracellular vesicles (EVs) are lipid-bilayer vesicles that mediate intercellular communication by transporting proteins, lipids, and regulatory RNAs, including microRNAs (miRNAs). Here, we investigated whether the...

Candida parapsilosis sensu stricto has emerged as a major cause of healthcare-associated candidemia, with increasing reports of fluconazole resistance worldwide. This resistance is most commonly associated with amino acid substitutions in Erg11p, particularly Y132F; however, regional variation in resistance mechanisms and clonal dissemination remains not fully understood. This study investigated the molecular epidemiology and...

Background Streptococcus pyogenes (GAS) causes diseases ranging from mild pharyngitis to severe invasive infections. The emm 1 type is the most prevalent worldwide, and a highly transmissible variant, M1 UK , characterized by increased speA expression, has recently emerged and spread globally. Objective To characterize the genomic diversity of invasive GAS isolates collected from severe cases and epidemiologically important ou...

Bovine mastitis is one of the major challenges in dairy production, causing significant economic losses and emphasizing the need for alternatives to the indiscriminate use of antibiotics. Palo Santo ( Bursera graveolens ) essential oil (BEO) presents recognized biological properties that can be enhanced through nanoengineered delivery systems. This study aimed to chemically characterize the BEO of B. graveolens , develop a nan...

The Cerrado biome, spanning ~2 million km 2 , is one of the most extensive and biodiverse tropical savannas, yet it is paradoxically dominated by only 30 hyperdominant tree species (~2% of all species, > 50% of all stems). However, their vulnerability to climate change and the effectiveness of current conservation efforts remain uncertain. By combining (i) species distribution models calibrated with edaphic‐climatic predictors...

Microplastics (MPs) ingestion in wild fish during the early stages remains a field with scarce information and contradictory findings in laboratory studies. This study evaluated whether MPs contamination of larval fish stages begins at the commencement of the exogenous feeding phase and whether different species and ontogenetic development stages exhibit different profiles of MPs contamination. We assessed, for the first time,...