Objective Geraniol (GO), a traditional plant-derived medicine, has demonstrated anti-osteoclastogenic properties that preserve bone integrity and inhibit bone resorption. This study aimed to evaluate the effect of GO in the adjuvant arthritis rat model, alone and combined with methotrexate (MX), with emphasis on miR-124 and miR-30a effect on the inflammasome (NLRP3)-related disease progression pathways. Methods Fourteen days p...

Viniferin, a resveratrol-derived compound that belongs to a group of plant-produced stilbenoids, functions as a natural defense against microbial invasion, toxins, infections, and ultraviolet radiation. Alpha-(α-) viniferin (trimer), beta-(β-) viniferin (dimer), delta-(δ-) viniferin (oxidative dehydrodimer), epsilon-(ε-) viniferin (distinct dehydrodimer), gamma-(γ-) viniferin (isomeric oligomer), vitisin A (R-viniferin), and v...

Assessment of acute toxicity of magnetic nanogel (MNG) is crucial to conclude the safe applicable dose and to warrant its application in aquaculture. Therefore, the current study is a novel step to assess behavior, neuro-stress response, hepato-renal, oxidative, and histopathological variations produced by MNG’ acute toxicity in Clarias gariepinus . Two experiments were conducted: the first was a determination of the 96-h leth...

Background Many drugs have been restricted in the treatment of gastric ulcers (GU). So, herbal medicines are now in great demand for their better cultural acceptability, compatibility, and minimal side effects. Therefore, our study aimed to assess the protective efficacy of Aloe vera gel and Geranium robertianum extracts against Aspirin®-induced GU in Wistar rats. Methods Antioxidant activity and chemical composition of both h...

The prevalence of obesity and its associated metabolic disorders, along with their healthcare costs, is rising exponentially. Irisin, an adipomyokine, may serve as a critical cross-organ messenger, linking skeletal muscle with adipose tissue and the liver to integrate the energy homeostasis under diet-induced obesity. We aimed to explore the putative role of irisin in the protection against obesity in a postmenopausal rat mode...