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Therapeutically relevant rimonabant exposure drives epigenetic remodeling in neuronal cells and rat brain tissueNARA Subscribed
Rimonabant (SR141716A), an inverse agonist of the cannabinoid receptor type 1 (CB 1 ), once approved for treating obesity and metabolic disorders, was withdrawn shortly after due to psychiatric and psychological adverse events (PPAEs), including depression and suicidality. Although its primary pharmacological mechanism of action is well-characterized, the molecular basis underlying these neuropsychiatric effects remains unclea...
Spatiotemporal groundwater recharge assessment under prolonged drought conditions in São Paulo State, BrazilNARA Subscribed
Following recent prolonged regional droughts, reliance on groundwater resources in São Paulo State, Brazil, has increased, emphasizing the need for robust evaluations of groundwater availability to support integrated water resources management. For this purpose, dependable methods for estimating groundwater recharge were applied. This paper focuses on one of the region’s most important aquifers, the Bauru Aquifer System (BAS),...
Under the current global biodiversity crisis, there is a need for automated and noninvasive monitoring techniques that can gather large amounts of data cost‐effectively at various ecological scales, from local to large spatial scales. These data can then be analyzed to inform stakeholders and decision‐makers. One such technique is passive acoustic monitoring, which is commonly coupled with automatic identification of animal sp...
Climate is a primary, but non‐stationary, driver of tree growth. Climate change is altering the sensitivity of forest growth to water availability and temperature over time. It is considered that pedunculate oak ( Quercus robur L.) will cope with the changing climatic conditions in Europe in the near future. However, while species distribution models project expansion zones, they also identify reductions in occurrence at the d...
The effects of global climate change on biodiversity and ecosystem functioning are unevenly distributed in the geographic space. Identifying sites more suitable to sustain biodiversity in a changing climate is essential to both species conservation and restoration strategies at different scales. Here, we map terrestrial climate‐resilient sites for biodiversity across Brazil to identify sites with greater chances of providing s...
Aim The urgency for remote, reliable and scalable biodiversity monitoring amidst mounting human pressures on ecosystems has sparked worldwide interest in Passive Acoustic Monitoring (PAM), which can track life underwater and on land. However, we lack a unified methodology to report this sampling effort and a comprehensive overview of PAM coverage to gauge its potential as a global research and monitoring tool. To address this...
Background: Priming strategies that improve the functionality of MSCs may be required to address issues limiting successful clinical translation of MSC therapies. For conditions requiring high trophic support such as brain and spinal cord injuries, priming MSCs to produce higher levels of trophic factors may be instrumental to facilitate translation of current MSC therapies. We developed and tested a novel molecular priming pa...
Camera trap surveys of A tlantic F orest mammals: A data set for analyses considering imperfect detection (2004–2020)NARA Subscribed
Camera traps became the main observational method of a myriad of species over large areas. Data sets from camera traps can be used to describe the patterns and monitor the occupancy, abundance, and richness of wildlife, essential information for conservation in times of rapid climate and land‐cover changes. Habitat loss and poaching are responsible for historical population losses of mammals in the Atlantic Forest biodiversity...
Dimethyl fumarate (DMF) is an old drug used for psoriasis treatment that has recently been repurposed to treat relapse–remitting multiple sclerosis, mostly due to its neuro- and immunomodulatory actions. However, mining of a pharmacovigilance database recently ranked DMF as the second pharmaceutical most associated with cognitive adverse events. To our best knowledge, the signaling mechanisms underlying its therapeutic and neu...