Sandra Rodrigues results 139
· Newest (Page 1/6, per page 25)
Author: Sandra Rodrigues ×Clear All Filters
Search Results
DNA barcoding uncovers two putative new species in Trachelyopterus (Siluriformes: Auchenipteridae)NARA Subscribed
Trachelyopterus is a cryptic genus within the Neotropical catfish family Auchenipteridae with a complex history of taxonomic revisions. Despite the notable morphological and genetic similarities among its species, some studies suggest that the genus harbours greater diversity than is currently recognized, including additional species yet to be formally described. One of the most widely used and effective approaches for investi...
Digoxin Derivative BD-8 Attenuates Oxidative Stress and Neuroinflammation in an LPS-Induced Experimental ModelNARA Subscribed
Chronic neuroinflammation contributes to neuronal damage through oxidative stress and inflammatory mediators, highlighting the need for novel therapeutic strategies. This study evaluated the cytotoxicity and neuroprotective effects of BD-8, a digoxin-derived cardiosteroid, in vitro and in vivo. BD-8 showed lower cytotoxicity than digoxin, with CC₅₀ values of 7.4 µM in SH-SY5Y cells and 8.5 µM in BV-2 cells, while digoxin prese...
Integration of Multi-Omics Data To Understand the Multifaceted Role of RAMP1 across Different Cancer TypesNARA Subscribed
Receptor Activity-Modifying Protein 1 (RAMP1) is a Calcitonin Receptor-Like Receptor (CALCRL)-associated protein with significant relevance in oncogenesis and tumor progression. It acts as a context-dependent allosteric modulator of GPCRs. This integrative review synthesizes evidence from multiple omics layers—transcriptomics, proteomics, epigenomics, and pan-cancer datasets—to clarify the role of RAMP1, its signaling pathways...
Neuroinflammation and RAMP1: the Role of the Peripheral and Central Nervous System in Tumor ProgressionNARA Subscribed
Calcitonin gene-related peptide (CGRP) and receptor activity modifier protein 1 (RAMP1) form a critical neuroimmunoendocrine axis in the modulation of neuroinflammation, pain, and tumor progression. CGRP, released by sensory and sympathetic fibers, is a potent vasodilator and nociceptive modulator; its action depends on the receptor composed of CALCRL and RAMP1. In the central nervous system, the activation of microglia and as...
Direct U–Pb dating of vitrinite in coalNARA Subscribed
Microplastics (MPs) ingestion in wild fish during the early stages remains a field with scarce information and contradictory findings in laboratory studies. This study evaluated whether MPs contamination of larval fish stages begins at the commencement of the exogenous feeding phase and whether different species and ontogenetic development stages exhibit different profiles of MPs contamination. We assessed, for the first time,...
Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R packag...