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Springer Nature1
Journal
Drug Delivery and Translational Research1
Publication Year
20261
Sean McCafferty results 1 · Newest (Page 1/1, per page 25)
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Mucosal administration of lipid nanoparticles containing self-amplifying mRNA induces local uptake and expression in a pig model as a potential vaccination platform against STIsNARA Subscribed
Drug Delivery and Translational Research · 2026 · Vol. 16 · Issue 1 · Springer
Ibe Van de Casteele; Magalie Plovyt; Magdalena Stuchlíková; Michiel Lanssens; Ben Verschueren; Quenten Denon; Paul Van der Meeren; Sean McCafferty; Arlieke Gitsels; Pieter Cornillie; Niek N. Sanders; Aster Vandierendonck; Katrien C. K. Poelaert; Daisy Vanrompay
Mucosal vaccination generates protective immune responses directly at the primary site of STI infection. However, the delivery of nanoparticles is hindered by the mucus barrier at these mucosal surfaces. Due to this interference, research on mucosal administration of self-amplifying (sa)-mRNA encapsulated in lipid nanoparticles (LNP) is currently limited and inconsistent. Some progress has been reported for nasal mRNA vaccinat...
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