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Sebastian Polak results 17 · Newest (Page 1/1, per page 25)
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Development and Implementation of a Hinderance-based In Vitro Model for Porous MembranesNARA Subscribed
The AAPS Journal · 2026 · Vol. 28 · Issue 4 · Springer
Daniel A. Paterson; Lucy Coleman; Yuri Dancik; Kanika Thakur; Yanling Zhang; Alice Maciel Tabosa; Sebastian Polak; James F. Clarke
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Virtual Bioequivalence Assessment of Long-acting Injectable Suspensions Using PBPK Modeling: Part 1. Impact of particle Size on Formulation VariabilityNARA Subscribed
The AAPS Journal · 2026 · Vol. 28 · Issue 3 · Springer
Natalie M. Morris; Alexandre Djehizian; Naresh Mittapelly; Krishna Chaitanya Telaprolu; Bryan W. Holland; Kevin McNally; Sebastian Polak; Masoud Jamei; Khondoker Alam; Eleftheria Tsakalozou; Mark Donnelly; Kairui Feng; Frederic Y. Bois
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Mechanistic Modelling of Lidocaine and Prilocaine Absorption from EMLA Cream upon Topical Application using Physiologically Based Pharmacokinetic ModellingNARA Subscribed
AAPS PharmSciTech · 2025 · Vol. 27 · Issue 1 · Springer
Krishna C. Telaprolu; Eleftheria Tsakalozou; Priyanka Ghosh; Khondoker Alam; Jeffrey E. Grice; Michael S. Roberts; Masoud Jamei; Sebastian Polak; James F. Clarke
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Applications of Modeling and Simulation Approaches in Support of Drug Product Development of Oral Dosage Forms and Locally Acting Drug Products: a Symposium SummaryNARA Subscribed
The AAPS Journal · 2023 · Vol. 25 · Issue 6 · Springer
Eleftheria Tsakalozou; Mohamed-Eslam F. Mohamed; Sebastian Polak; Tycho Heimbach
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Physiologically based modelling of dermal absorption and kinetics of consumer-relevant chemicals: A case study with exposure to bisphenol A from thermal paperNARA Subscribed
Toxicology and Applied Pharmacology · 2023 · Vol. 459 · Academic Press
Barbara Wiśniowska; Susanne Linke; Sebastian Polak; Zofia Bielecka; Andreas Luch; Ralph Pirow
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How circadian variability of the heart rate and plasma electrolytes concentration influence the cardiac electrophysiology – model-based case studyNARA Subscribed
Journal of Pharmacokinetics and Pharmacodynamics · 2021 · Vol. 48 · Issue 3 · Springer
Barbara Wiśniowska; Zofia M. Bielecka; Sebastian Polak
The circadian rhythm of cardiac electrophysiology is dependent on many physiological and biochemical factors. Provided, that models describing the circadian patterns of cardiac activity and/or electrophysiology which have been verified to the acceptable level, modeling and simulation can give answers to many of heart chronotherapy questions. The aim of the study was to assess the performance of the circadian models implemented...
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Physiologically based pharmacokinetic-quantitative systems toxicology and safety (PBPK-QSTS) modeling approach applied to predict the variability of amitriptyline pharmacokinetics and cardiac safety in populations and in individualsNARA Subscribed
Journal of Pharmacokinetics and Pharmacodynamics · 2018 · Vol. 45 · Issue 5 · Springer
Zofia Tylutki; Aleksander Mendyk; Sebastian Polak
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Virtual Thorough QT (TQT) Trial—Extrapolation of In Vitro Cardiac Safety Data to In Vivo Situation Using Multi-Scale Physiologically Based Ventricular Cell-wall Model Exemplified with Tolterodine and FesoterodineNARA Subscribed
The AAPS Journal · 2018 · Vol. 20 · Issue 5 · Springer
Nikunjkumar Patel; Barbara Wisniowska; Sebastian Polak
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Drug–physiology interaction and its influence on the QT prolongation-mechanistic modeling studyNARA Subscribed
Journal of Pharmacokinetics and Pharmacodynamics · 2018 · Vol. 45 · Issue 3 · Springer
Barbara Wiśniowska; Sebastian Polak
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Quantitative approach for cardiac risk assessment and interpretation in tuberculosis drug developmentNARA Subscribed
Journal of Pharmacokinetics and Pharmacodynamics · 2018 · Vol. 45 · Issue 3 · Springer
Sebastian Polak; Klaus Romero; Alexander Berg; Nikunjkumar Patel; Masoud Jamei; David Hermann; Debra Hanna
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Towards Bridging Translational Gap in Cardiotoxicity Prediction: an Application of Progressive Cardiac Risk Assessment Strategy in TdP Risk Assessment of MoxifloxacinNARA Subscribed
The AAPS Journal · 2018 · Vol. 20 · Issue 3 · Springer
Nikunjkumar Patel; Oliver Hatley; Alexander Berg; Klaus Romero; Barbara Wisniowska; Debra Hanna; David Hermann; Sebastian Polak
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Real Patient and its Virtual Twin: Application of Quantitative Systems Toxicology Modelling in the Cardiac Safety Assessment of CitalopramNARA Subscribed
The AAPS Journal · 2018 · Vol. 20 · Issue 1 · Springer
Nikunjkumar Patel; Barbara Wiśniowska; Masoud Jamei; Sebastian Polak
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The Role of Interaction Model in Simulation of Drug Interactions and QT ProlongationNARA Subscribed
Current Pharmacology Reports · 2016 · Vol. 2 · Issue 6 · Springer
Barbara Wiśniowska; Sebastian Polak
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Top-down, Bottom-up and Middle-out Strategies for Drug Cardiac Safety Assessment via Modeling and SimulationsNARA Subscribed
Current Pharmacology Reports · 2016 · Vol. 2 · Issue 4 · Springer
Zofia Tylutki; Sebastian Polak; Barbara Wiśniowska
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Early Drug Discovery Prediction of Proarrhythmia Potential and Its CovariatesNARA Subscribed
The AAPS Journal · 2015 · Vol. 17 · Issue 4 · Springer
Sebastian Polak; Michael K. Pugsley; Norman Stockbridge; Christine Garnett; Barbara Wiśniowska
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Assessment of inter-individual variability in predicted phenytoin clearanceNARA Subscribed
European Journal of Clinical Pharmacology · 2009 · Vol. 65 · Issue 12 · Springer
Thomas M. Polasek; Sebastian Polak; Matthew P. Doogue; Amin Rostami-Hodjegan; John O. Miners
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Population-Based Mechanistic Prediction of Oral Drug AbsorptionNARA Subscribed
The AAPS Journal · 2009 · Vol. 11 · Issue 2 · Springer
Masoud Jamei; David Turner; Jiansong Yang; Sibylle Neuhoff; Sebastian Polak; Amin Rostami-Hodjegan; Geoffrey Tucker
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