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Effects of Low-Intensity Aaerobic Training on Cardiac Dysfunction and Myocardial Fibrosis Induced by Doxorubicin in Wistar RatsNARA Subscribed
Doxorubicin-induced cardiotoxicity is a major limitation in cancer therapy. Physical exercise has been proposed as a non-pharmacological strategy capable of mitigating these effects through cardiovascular adaptations. This study evaluated whether low-intensity aerobic training attenuates cardiac dysfunction induced by doxorubicin. Twenty-five adult male Wistar rats (450 and 500 g) were allocated and divided into four groups: C...
Aim We investigate the distribution of dispersal modes — endozoochory (via animal ingestion), synzoochory (via animal seed accumulation) and anemochory (via wind)—and seed mass of woody plants across Brazilian ecosystems, testing whether their relative abundance in local plant communities could be predicted by climate, edaphic factors and dispersal agents (e.g., the main vectors moving seeds). We expected climate to be the mai...
A de novo Loss-of-function Variant in RAPGEF6 Supports its Role in Neuropsychiatric DisordersNARA Subscribed
RAPGEF6 is a member of the guanine nucleotide exchange factor (GEF) subfamily that acts on Rap small GTPases and contains a Ras/Rap-associating domain. Although deficiency of this gene has previously been linked to schizophrenia, no MIM phenotype entry currently associates RAPGEF6 with a defined clinical condition. In this study, trio-based whole-exome sequencing (WES) was performed in an individual presenting with psychiatric...
Cat-transmitted Sporotrichosis: A Clonal Household Outbreak with Atypical Human and Canine Disease Due to Sporothrix brasiliensisNARA Subscribed
The epidemiology of sporotrichosis, a neglected mycosis caused by Sporothrix species, has shifted in South America from classic sapronosis to urban zoonosis driven by feline transmission of the hypervirulent Sporothrix brasiliensis . However, the fine-scale transmission dynamics of this epidemic, particularly within households, remain poorly understood. Here, we dissect an intrafamilial outbreak in Brazil involving a cat (the...
Conservation Planning and Reporting Implications of qPCR-based Multi-species eDNA Detection Under EU Environmental RegulationsNARA Subscribed
European Union (EU) legislation supports the conservation of endangered freshwater species through the Habitats Directive (HD, 92/43/EEC) and the Water Framework Directive (WFD, 2000/60/EC), and the eradication of Invasive Alien Species (IAS) through the Regulation 1143/2014. Periodic monitoring and reporting on the species listed in these regulations are mandatory for EU Member States. Quantitative PCR environmental DNA (qPCR...
Lewy body disease (LBD) and Alzheimer’s disease (AD) are the most common causes of cognitive decline and dementia and are associated with characteristic alterations in resting-state electroencephalographic (rsEEG) activity. This multicenter exploratory study investigated periodic and aperiodic rsEEG features in patients with cognitive decline due to Lewy body disease (LBCD) and Alzheimer’s disease (ADCD), compared with cogniti...
Once widespread in Italy, in the last century the Eurasian otter ( Lutra lutra ) went to the brink of extinction in this country, only surviving in a few southern river basins. Being included in the Habitats Directive 92/43/EEC, it is mandatory for State Members to monitor its conservation status over time, making cost effective and accurate monitoring protocols a relevant issue. We compared the efficiency of environmental DNA...
The Cerrado biome, spanning ~2 million km 2 , is one of the most extensive and biodiverse tropical savannas, yet it is paradoxically dominated by only 30 hyperdominant tree species (~2% of all species, > 50% of all stems). However, their vulnerability to climate change and the effectiveness of current conservation efforts remain uncertain. By combining (i) species distribution models calibrated with edaphic‐climatic predictors...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
Purpose Bloodstream infections (BSIs) pose a significant health threat, requiring effective diagnostic processes to ensure appropriate treatment. Monitoring the quality of blood cultures (BCs) process (the cornerstone of BSIs etiological diagnosis) is critical. This study aimed to describe an automated tool, BD DREAM™ (Digital Remote Extraction Analysis & Monitoring), designed for monitoring key performance indicators (KPIs) i...