Purpose Inhalable liquid formulation of endolysins represents a promising alternative to conventional antibiotics. Dry powder formulations offer improved stability for endolysin pulmonary delivery. This study aimed to evaluate the efficacy of an inhalable dry powder or liquid formulation of endolysin Cpl-1 alone and to compare it with liquid combinations of Cpl-1 with either gentamicin or endolysin Pal in a murine model of S....

Objective Assessing circulatory hemodynamics in-vitro is crucial for cardiovascular device design before in-vivo testing. Current mock circulation loops (MCLs) rely on simplified, lumped-parameter hydraulic representations of human circulation. There is a need for a more sophisticated MCL that can accurately represent the human circulatory physiology and allow for critical assessment of device-supported hemodynamics. Methods A...

Climate change undermines the foundations of food and nutrition security, making it crucial to understand and improve the current research collaborations striving to fill knowledge gaps about the impacts on food systems. This study focuses on the network of research actors working on food systems and climate change in Pacific Island Countries and Territories (PICTs), a region particularly vulnerable to climate change, and acti...

In July 2021 extreme rainfall across Western Europe caused severe flooding and substantial impacts, including over 200 fatalities and extensive infrastructure damage within Germany and the Benelux countries. After the event, a hydrological assessment and a probabilistic event attribution analysis of rainfall data were initiated and complemented by discussing the vulnerability and exposure context. The global mean surface tempe...