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Managing the Unmanageable: Understanding the Competing Effects of Salinity and Nutrient Loading on Estuarine Water QualityNARA Subscribed
Changing climatic conditions that can alter physical characteristics of surface waters may limit the effectiveness of conventional approaches to nutrient management. This study evaluated the competing effects of nutrient loads and changing salinity on chlorophyll-a dynamics in Tampa Bay (Florida, USA). This estuary has demonstrated long-term recovery of water quality primarily through wastewater infrastructure improvements, wh...
We have attempted to re-establish bay scallops to the Virginia, U.S.A. coastal bays and document the dynamics of the restoration effort. Bay scallops ( Argopecten irradians ) once flourished in the eelgrass ( Zostera marina ) of the Virginia coastal bays. Eelgrass wasting disease led to declines, and both eelgrass and scallops were completely lost after a 1933 hurricane. The Virginia Institute of Marine Science (VIMS) led a su...
Culvert construction at stream crossing sites can lead to zones of high-velocity water flow which can disrupt the dispersal and connectivity of species of greatest conservation need (SGCN) in Texas. To help inform effective culvert design, the swimming performance of the following seven fish species has been measured, the first three of which are SGCN themselves, and the last four serve as hosts for glochidia of SGCN mussels (...
Radiopaque microsphere-hydrogel composite for extended-release intratumoral immunotherapy in a large animal modelNARA Subscribed
Intratumoral injection of immune stimulants could potentially reverse the immunosuppressive tumor microenvironment, but the injected drug rapidly washes out into the systemic circulation. This results in systemic toxicity, and reduced efficacy, potentially requiring daily injections to generate an antitumor immune response. To address this problem, we developed an extended-release hydrogel that retains the immunotherapy agent...
The Role of Gene Flow in the Diversification of the Monkey Treefrog Complex Across the South American Dry DiagonalNARA Subscribed
Understanding Neotropical megadiversity remains challenging due to fundamental taxonomic issues, including identifying and describing cryptic species and their distribution, and the limited knowledge of key factors driving biological diversification. Such challenges are especially prominent in diverse clades with high levels of cryptic species, such as many Neotropical frogs. Herein, we conduct a mitochondrial phylogenetic stu...
Promoting Research Excellence in Down Syndrome: Proceedings of the 5th International Conference of the Trisomy 21 Research SocietyNARA Subscribed
Down syndrome (DS), or trisomy 21 (T21), represents the most common genetic cause of intellectual disability worldwide and is associated with a wide range of medical, developmental, and neurodegenerative conditions, including a universal predisposition to early-onset Alzheimer’s disease (AD). Since its establishment in 2014, the Trisomy 21 Research Society (T21RS) has provided a global forum for advancing DS research across di...
The Phylogenetic Position of the Extinct Hawaiian Honeyeaters: Overcoming the Limitations of Historical DNANARA Subscribed
Mohoidae, the Hawaiian honeyeaters, are a group of extinct birds that once inhabited the Hawaiian Islands. Their genetic data are only available from historical museum specimens, so it is based on highly fragmented and damaged DNA. Sequences assembled from historical specimens can have large amounts of missing data and they often result in exceptionally long terminal branches in phylogenies. These long branches can distort est...
Lake sturgeon ( Acipenser fulvescens ) growth and longevity estimated from adult capture–mark–recapture dataNARA Subscribed
Effective fishery management policy depends on accurate life‐history data, particularly for harvested species. Longevity is a core life‐history trait that is directly related to annual survival and lifetime reproductive potential, but fish longevity is generally not well documented, particularly for long‐lived species. We used capture–mark–recapture data spanning 44 years as an alternative method to estimate sex‐specific adult...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Addressing urgent conservation issues, such as the drastic declines of North American migratory birds, requires creative, evidence‐based, efficient, and collaborative approaches. The abundance of over 50% of monitored North American shorebird populations has declined by over 50% since 1980. To address these declines, we developed a partnership of scientists and practitioners called the Shorebird Science and Conservation Collec...