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GlyT1 inhibition enhances working memory in the mouse TUNL task and normalizes NMDA antagonist–induced network activityNARA Subscribed
Rationale Working memory deficits are a core feature of psychiatric disorders such as schizophrenia and bipolar disorder, yet effective pharmacological strategies remain elusive. The trial unique non-matching to location (TUNL) task offers improved face validity compared to traditional maze-based tasks; however, no systemically administered compound has been shown to enhance performance in this task in naïve mice. Furthermore,...
Impacts of climate change on biodiversity and ecosystems in Bavaria: a sectoral analysisNARA Subscribed
Climate change is expected to create a range of impacts on biodiversity, land use, and economic activities, but those sector impacts are rarely analysed together. Here, we assess how climate change and socioeconomic narratives will affect land use and biodiversity in the state of Bavaria, Germany. We apply a multi-sectoral modelling approach with two climate projections (RCP 2.6 and 8.5) downscaled from three different climate...
A geological and geophysical database for the assessment of offshore freshened groundwater resourcesNARA Subscribed
Fresh groundwater resources in coastal regions are vital for modern society, but are under considerable pressure due to population growth, seasonal peaks in demand, pollution and climate change. In recent years, interest in offshore freshened groundwater (OFG) has surged, as potential resource for addressing these challenges. Recent studies have documented OFG occurrences on many continental margins and islands, with global vo...
Tracking reduction-induced molecular changes in pathological free light chains by SV-AUCNARA Subscribed
Multiple myeloma is a blood cancer characterized by plasma cell proliferation and excessive production of monoclonal proteins, often leading to renal complications and other forms of organ damage. A set of nine immunoglobulin free light chain (FLC) samples purified from urine of multiple myeloma patients was subjected to sedimentation velocity analysis. Aim of the study was to track changes of the oligomerization state of each...
Climate change impacts on a sedimentary coast—a regional synthesis from genes to ecosystemsNARA Subscribed
Climate change effects on coastal ecosystems vary on large spatial scales, but can also be highly site dependent at the regional level. The Wadden Sea in the south-eastern North Sea is warming faster than many other temperate coastal areas, with surface seawater temperature increasing by almost 2 °C over the last 60 years, nearly double the global ocean mean increase. Climate warming is accompanied by rising sea levels, which...