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Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibitionNARA Subscribed
The tumour suppressor p16/CDKN2A and the metabolic gene, methyl-thio-adenosine phosphorylase (MTAP), are frequently co-deleted in some of the most aggressive and currently untreatable cancers. Cells with MTAP deletion are vulnerable to inhibition of the metabolic enzyme, methionine-adenosyl transferase 2A (MAT2A), and the protein arginine methyl transferase (PRMT5). This synthetic lethality has paved the way for the rapid deve...
Meeting Paris agreement objectives will temper seabird winter distribution shifts in the North Atlantic OceanNARA Subscribed
We explored the implications of reaching the Paris Agreement Objective of limiting global warming to Alle alle , Fratercula arctica , Uria aalge , Uria lomvia and Rissa tridactyla ) using tracking data for ~1500 individuals through resource selection functions based on mechanistic modeling of seabird energy requirements, and a dynamic bioclimate envelope model of seabird prey. Future winter distributions were predicted to shif...
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