The Tricycle Protocol is a One Health initiative that involves monitoring extended-spectrum β-lactamase-producing Escherichia coli (ESBL-Ec), an opportunistic intestinal and extraintestinal pathogen that is recognized as critically important for the development of new antimicrobial agents and as a key indicator of water, food, and environmental contamination. This study aimed to detect and characterize, phenotypically and geno...

Rhodococcus equi is an important bacterium that affects foals up to six months of age, especially those that are immunocompromised. The main manifestation is pyogranulomatous pneumonia; nevertheless, extrapulmonary lesions have not only been reported, but are not uncommon, including arthritis and osteomyelitis. Despite the widespread occurrence of rhodococcosis, the macro- and microscopic lesions in the musculoskeletal system...

Burkholderia cenocepacia is an important pathogen in cystic fibrosis (CF) patients, responsible for chronic lung infections and, in severe cases, cepacia syndrome (CS), characterized by necrotizing pneumonia, bacteremia, and high mortality. Epidemic lineages, such as B. cenocepacia J2315 (ET12) and ST32, are highly transmissible and frequently associated with CS. In this study, five B. cenocepacia isolates recovered from sputu...

6-Cyanodopamine (6-CYD) is a recently identified endogenous catecholamine that exerts positive chronotropic and inotropic actions, but its occurrence in vascular tissue and effects on vascular reactivity are unknown. In endothelium-intact and endothelium-denuded rabbit isolated aortic rings, we investigated the basal release of 6-CYD and its effects on aortic smooth muscle reactivity. 6-Cyanodopamine release was quantified by...

Multiform glioblastoma (GBM) is the most aggressive primary brain tumor, associated with high heterogeneity, treatment resistance, and poor survival. Temozolomide (TMZ), although the main chemotherapeutic agent used, shows limited efficacy due to low solubility, chemical instability, and acquired resistance. In this context, nanostructured systems can enhance their antitumor efficacy. This study aimed to develop and characteri...

Climate change has intensified water scarcity, increasing the use of saline water for irrigation. This practice may compromise the sustainability of salt-sensitive crops, such as sugarcane, which is essential for bioenergy production. A potential solution is to adopt management practices based on salt leaching. This study evaluated the effects of salinity on sugarcane yield, technological quality, and economic performance, as...

Cantharellus is an important genus of edible fungi with a worldwide distribution, whose species are recognized for their exceptional taste, beauty, and unique texture. Species of Cantharellus are terrestrial ectomycorrhizal fungi valued for their nutritional and medicinal properties, with demonstrated therapeutic potential due to their anti-inflammatory, antimicrobial, and antigenotoxic activities. Cantharellus guyanensis , or...

Receptor Activity-Modifying Protein 1 (RAMP1) is a Calcitonin Receptor-Like Receptor (CALCRL)-associated protein with significant relevance in oncogenesis and tumor progression. It acts as a context-dependent allosteric modulator of GPCRs. This integrative review synthesizes evidence from multiple omics layers—transcriptomics, proteomics, epigenomics, and pan-cancer datasets—to clarify the role of RAMP1, its signaling pathways...

Although biomedical engineering (BME) is a profession with ethical responsibilities comparable to those in medicine, it has, until now, lacked a counterpart to the Hippocratic Oath. While professional societies have established codes of ethics for biomedical engineers, these documents lack the symbolic and ceremonial significance of an oath or pledge. By contrast, the recitation of the Hippocratic Oath, or its modern version,...