Deficits in cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) may indicate vulnerability to vascular dysfunction and cognitive impairment. Prior findings on age-related change in CVR are mixed, and no studies to date have investigated age group differences in spontaneous CVR (sCVR) at rest. The present study compared whole brain and regional sCVR at rest between 24 healthy younger adults (ages 18–34) and 163 cogni...

Islands are model systems for testing and developing ecological theories. Despite extensive research on island biodiversity, the importance of the biogeographic context for biodiversity–stability relationships is poorly understood. We addressed this knowledge gap by integrating the Equilibrium Theory of Island Biogeography (ETIB) with a functional perspective to explore island biodiversity–stability relationships. We conducted...

Individual imaging and fluid biomarkers provide insights into specific components of brain health, but integrated multimodal approaches are necessary to capture the complex, interrelated biological systems that contribute to brain homeostasis and neurodegenerative disease. Using data from the Brain and Cognitive Health (BACH) cohort study ( N = 127; mean age = 67 years, 68% women), we performed an exploratory factor analysis t...