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International Journal of Peptide Research and Therapeutics · 2026 · Vol. 32 · Issue 2 · Springer
Purpose Tirzepatide is an effective dual GLP-1 and GIP receptor agonist for type 2 diabetes and obesity but faces challenges with low oral bioavailability and stability. Currently, tirzepatide is produced industrially via solid-phase peptide synthesis (SPSS), allows incorporation of noncanonical residues but limited in scalability for rapid mutant generation and biological delivery strategies. This study aimed to develop a mic...