Yanli Fu results 38
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Incorporation of D-amino Acids and Ornithines into Tirzepatide by Biosynthesis in E. ColiNARA Subscribed
Purpose Tirzepatide is an effective dual GLP-1 and GIP receptor agonist for type 2 diabetes and obesity but faces challenges with low oral bioavailability and stability. Currently, tirzepatide is produced industrially via solid-phase peptide synthesis (SPSS), allows incorporation of noncanonical residues but limited in scalability for rapid mutant generation and biological delivery strategies. This study aimed to develop a mic...
Prof Stephen P. Long, FRS (1950–2025)NARA Subscribed
Gut microbiota bridges dietary nutrients and host immunityNARA Subscribed