Distal cholangiocarcinoma (dCCA) is a malignant tumor characterized by a challenging diagnosis, high invasiveness, and extremely poor prognosis. Research on dCCA is limited by the scarcity of reliable patient-derived preclinical tumor models. This study established a novel human distal cholangiocarcinoma cell line, CBC3T-3, and systematically characterized its biological properties, genomic features, and potential for clinical...

Natural coastlines are vital for ecological security and sustainable development. To mitigate their decline, China has implemented requisition-compensation balance policy (RCBP) for coastlines, adapted from the management of cultivated land. This study systematically reviews the policy’s institutional evolution and highlights fundamental distinctions between coastlines and cultivated land in functional services, spatial hetero...