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Cation Channel TMEM63A Autonomously Facilitates Oligodendrocyte Differentiation at an Early StageNARA Subscribed
Accurate timing of myelination is crucial for the proper functioning of the central nervous system. Here, we identified a de novo heterozygous mutation in TMEM63A (c.1894G>A; p. Ala632Thr) in a 7-year-old boy exhibiting hypomyelination. A Ca 2+ influx assay suggested that this is a loss-of-function mutation. To explore how TMEM63A deficiency causes hypomyelination, we generated Tmem63a knockout mice. Genetic deletion of TMEM63...
The Yellow Sea Cold Water Mass (YSCWM) is one of the most prominent hydrological features of the Yellow Sea. As a low-temperature, nutrient-rich subsurface water mass, the YSCWM fundamentally regulates biogeochemical cycles, functions of marine ecosystems, and fishery resources of the YS. In boreal summer, the YSCWM shows a robust triple-core structure, in which the western component, dubbed the “western YSCWM”, is revisited i...