A previous study in our laboratory revealed that microRNA‐33 (miR‐33) regulated autophagy initiation and inflammatory response by targeting Atg5 ; furthermore, in this study, chloroquine (CQ), lipopolysaccharide (LPS) and the miR‐33 inhibitor were transfected into Ctenopharyngodon idella kidney (CIK) cells to explore whether miR‐33 regulated late‐stage autophagy and inflammatory response induced by LPS. The results showed that...

MicroRNA‐33 (miR‐33) plays a critical role in the regulation of autophagy and inflammatory responses. In this study, C. idella kidney (CIK) cells were transfected with a miR‐33 mimic or inhibitor and Atg5 was overexpressed or silenced to elucidate the regulatory mechanism of miR‐33. Our findings revealed that the miR‐33 mimic significantly decreased the expression of LC3B (a marker of autophagy activation), and the level of au...