Hypertrophic scars (HS) are fibrotic skin disorders driven by abnormal fibroblast activity. The molecular mechanisms underlying HS remain incompletely understood, particularly the role of non-coding RNAs. Expression levels of lncRNA TUG1, miR-627, and IGF1R were measured in HS tissues and fibroblasts using qRT-PCR and Western blotting. Dual-luciferase assays validated direct interactions. Functional effects of TUG1 and miR-627...

Integrated Sea-land management is an important feature of ecosystem-based management, and it is also the trend of marine spatial planning. China is one of the first countries worldwide to implement marine spatial planning which is mainly expressed as marine functional zoning (MFZ), and it has established a coastline management system for the connection between marine management and land management. In this paper, 18 national a...

Nutrients are crucial factors for the growth of phytoplankton, and their biogeochemical processes directly impact marine biodiversity. In this study, based on two cruise observations in spring and summer of 2024, the seasonal and spatial variations of nutrients, chlorophyll a, and other ecological indicators in Daya Bay were explored. The results indicated that the average concentrations of dissolved inorganic nitrogen and sil...

Brain metastasis (BM) in laryngeal squamous cell carcinoma (LSCC) is uncommon but prognosis is poor. Anti-PD-1 immunotherapy benefits some advanced LSCC cases, yet its efficiency is limited by tumor complexity. We analyzed paired metastatic tumor samples from before and after immunotherapy using single-cell RNA sequencing (scRNA-seq), along with a primary LSCC dataset and bulk RNA sequencing. This identified changes post-immun...