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Mechanisms of dyspnoea and exercise intolerance in smokers with preserved ratio impaired spirometryNARA Subscribed
Purpose Smokers with preserved ratio impaired spirometry (PRISm) present reduced forced expiratory volume in the first second (FEV₁ < 80% predicted) but preserved FEV 1 /forced vital capacity (FVC) ≥ 0.7. Although they do not meet diagnostic criteria for chronic obstructive pulmonary disease (COPD), they often report respiratory symptoms and exercise intolerance. We aimed to compare sensory and physiological responses to exerc...
Type-specific sensitivity versus detection breadth in HPV diagnostics: improved analytical detection of HPV16/18 by nested PCRNARA Subscribed
Accurate detection of high-risk human papillomavirus (HPV) is central to cervical cancer screening. Current diagnostic strategies increasingly prioritize broad-spectrum assays to maximize genotype coverage. However, theoretical genotype breadth does not necessarily translate into effective sample-level detection when clinically dominant targets are present at low copy number. Here, we evaluated this analytical trade-off using...
Background Elderly patients are increasingly being offered allogeneic hematopoietic cell transplantation (HCT), and several strategies have been developed to meet their needs. The objective of the current study was to report the feasibility of a reduced-intensity busulfan/fludarabine conditioning regimen with total marrow irradiation in older patients. Methods This single-center study included 28 patients aged 60–77 years with...
Identification of a capsid-derived Zika virus epitope with high IgG discriminatory performanceNARA Subscribed
The identification of specific serological targets for Orthoflavivirus zikaense (ZIKV) remains challenging due to the high degree of structural similarity and antibody cross-reactivity among co-circulating arboviruses, particularly dengue virus (DENV). In this context, immunoinformatics-based approaches may contribute to the rational selection of candidate epitopes with potentially improved analytical specificity. In the prese...
Performance-oriented parallel upscaling of river drainage networks for large data setsNARA Subscribed
Extracting coarse-resolution river drainage networks from fine-resolution DEM or DTM is essential for large-scale hydrological and environmental modeling. Flow direction upscaling methods are preferred for preserving drainage patterns, but they face significant computational challenges when handling massive fine-resolution datasets. This study introduces eCOTAT + , an enhanced version of the COTAT + algorithm, designed to impr...
Description and Patterns of Hyperostosis in Plata Pompano, Trachinotus marginatus Cuvier, 1832NARA Subscribed
This study describes the occurrence of hyperostosis, to the best of our knowledge, for the first time in Trachinotus marginatus Cuvier 1832 and examines its patterns in 21 specimens from Rio de Janeiro, Brazil. Radiographic images revealed the presence of the condition in 76.2% of the individuals, affecting five distinct bone regions: supraoccipital (76.2%), dorsal‐fin pterygiophore (52.3%), anal‐fin pterygiophore (9.5%), rib...