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Multi‐Model Ensembles in Ecosystem Modeling: Challenges and Best Practices for Decision‐MakingNARA Subscribed
Ecosystem models are increasingly central to the decision‐making for environmental policy, conservation planning, and climate‐related investments. Yet, the growing reliance on Multi‐Model Ensembles (MMEs) of ecosystem models by practitioners and policymakers, sometimes under tight timelines and imperfect information, has frequently outpaced the scientific rigor required to ensure ensemble reliability. Here, MMEs refer to appro...
Vertical Bending Moment in Extreme Regular Waves—Benchmarking of Numerical Codes Against Model TestsOA Marine
A benchmark study of 10 different numerical methods for ship motion and load assessment is presented. Pitch motions and midship vertical bending moments are compared to model test results for a containership at zero speed in head regular waves. The wave steepness is varied from 2.1% to 10.5%. The model tests show that pitch and the vertical bending moment (VBM) display nonlinear behavior even for low-steepness waves. It is dem...
Technical Considerations of Pharmacokinetic Assays for LNP-mRNA Drug Products by RT-qPCRNARA Subscribed
Lipid nanoparticle-messenger RNA (LNP-mRNA) drug products are a growing class of drug modalities. The unique composition of these drug products requires multiple measurements to account for the different components of these drug modalities. Pharmacokinetic (PK) measurements include measurement of the encapsulated mRNA and components of the LNP in circulation to understand the effectiveness of the therapeutic mRNA. The PK measu...