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Emerging SARS-CoV-2 variants, notably Omicron, continue to remain a formidable challenge to worldwide public health. The SARS-CoV-2 receptor-binding domain (RBD) is a hotspot for mutations, reflecting its critical role at the ACE2 interface during viral entry. Here, we comprehensively investigated the impact of RBD mutations, including 5 variants of concern (VOC) or interest—including Omicron (BA.2)—and 33 common point mutatio...
Reactive transport modelling under supercritical conditionsNARA Subscribed
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Prioritization of knowledge‐needs to achieve best practices for bottom trawling in relation to seabed habitatsNARA Subscribed
Management and technical approaches that achieve a sustainable level of fish production while at the same time minimizing or limiting the wider ecological effects caused through fishing gear contact with the seabed might be considered to be ‘best practice’. To identify future knowledge‐needs that would help to support a transition towards the adoption of best practices for trawling, a prioritization exercise was undertaken wit...
Remote climate forcing of decadal‐scale regime shifts in Northwest Atlantic shelf ecosystemsNARA Subscribed
Decadal‐scale regime shifts in Northwest Atlantic shelf ecosystems can be remotely forced by climate‐associated atmosphere‐ocean interactions in the North Atlantic and Arctic Ocean Basins. This remote climate forcing is mediated primarily by basin‐ and hemispheric‐scale changes in ocean circulation. We review and synthesize results from process‐oriented field studies and retrospective analyses of time‐series data to document t...
Ethanol Fuels: E10 or E85 – Life Cycle Perspectives (5 pp)NARA Subscribed