Increasing life expectancy has been accompanied by a higher prevalence of age-associated conditions, underscoring the need to better understand biological mechanisms of aging and to identify accessible biomarkers. Extracellular vesicles (EVs) are lipid-bilayer vesicles that mediate intercellular communication by transporting proteins, lipids, and regulatory RNAs, including microRNAs (miRNAs). Here, we investigated whether the...

Background Chronic inflammatory pain is associated with persistent sensory and immune dysregulation. We evaluated the therapeutic efficacy of two cannabinoids formulations—Cannabigerol (CBG) and Standardized Full-Spectrum Cannabis Extract (FULL) in a preclinical model of acute and Chronic inflammatory pain and examined their effects on peripheral and central inflammatory mediators. Methods Cannabinoid analgesic effects were as...

The American manatee ( Trichechus manatus ) requires freshwater mainly from rivers and springs to maintain osmoregulatory balance in saline environments. However, in Brazil's semi‐arid Potiguar Basin, manatees now rely solely on submarine freshwater springs because hypersaline estuaries have become unsuitable sources of freshwater. We applied MaxEnt modeling to presence‐only data (sightings and filtered telemetry records) to p...

Sternochetus mangiferae is a pest of mangoes, occurring worldwide in regions where mangoes are cultivated. In Brazil, this insect was first detected in 2014 in Seropédica, Rio de Janeiro, and since then, various measures and studies have been conducted to contain, monitor and potentially eradicate it. Semiochemicals may provide feasible targets to develop sensitive detection and monitoring tools. Therefore, this study aimed to...

Bees play a pivotal role in terrestrial environments. Urbanization can affect these organisms and the ecosystem services they provide. However, knowledge of the global diversity of urban bees is limited. Thus, we summarized data on urban bee species identities and occurrences; compared distributions of all bees with those found in urban environments; described traits and resource collection across latitudinal regions; and dete...

Bees are essential for ecosystem functioning, pollinating many wild and crop plant species. Predicting which species are most vulnerable to global changes, and how their loss may impact ecosystems and human well-being, is critical. Comprehensive information on bee response and effect traits is fundamental to these assessments. However, the Raunkiærian shortfall—insufficient trait data—remains significant for bees, particularly...

Ocean Alkalinity Enhancement (OAE) is a promising carbon dioxide removal strategy, but its ecological impacts on marine microbial communities under varying nutrient conditions remain poorly understood. We conducted laboratory incubations using a natural North Atlantic microbial assemblage to investigate the response to OAE under both natural and nutrient-enriched regimes. We tracked phytoplankton and bacterioplankton dynamics,...