Neuroblastoma (NB) is a formidable challenge in pediatric oncology due to its intricate molecular landscape, necessitating multifaceted therapeutic approaches. ONC201 is an imipridone antibiotic compound with a promising drug candidate leveraging its potent anticancer properties against the mitochondrial proteases ClpP and ClpX. Despite demonstrating early clinical promise, particularly in MYCN -amplified NB, its efficacy in n...

Purpose Cervical total disc replacement (TDR) is commonly performed to treat degenerative cervical spondylosis, but it often faces challenges such as implant wear and migration. This study aimed to develop and evaluate a novel 3D-printed TDR featuring a titanium endplate and a lattice-structured poly-ether-ether-ketone (PEEK) design. The primary objective was to replicate the natural motion of the cervical disc while addressin...

This study presents an optimized system for ship route planning. Computational fluid dynamics simulations were used to modify Kwon’s semi-empirical speed loss estimation method, enabling efficient route planning under variable sea conditions. The study focused on improving the prediction of speed loss in irregular waves for container ships and further applying this to ship-optimized voyage planning. Dynamic programming was use...