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Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volumeNARA Subscribed
The concept of age acceleration, the difference between biological age and chronological age, is of growing interest, particularly with respect to age-related disorders, such as Alzheimer’s Disease (AD). Whilst studies have reported associations with AD risk and related phenotypes, there remains a lack of consensus on these associations. Here we aimed to comprehensively investigate the relationship between five recognised meas...
The shoaling transformation from generally linear deep-water waves to asymmetric shallow-water waves modifies wave shapes and causes near-bed orbital velocities to become asymmetrical, contributing to net sediment transport. In this work, we used two methods to estimate the asymmetric wave shape from data at three sites. The first method converted wave measurements made at the surface to idealized near-bottom wave-orbital velo...
Purpose This work describes a staged approach to the application of pharmacokinetic-pharmacodynamic (PK-PD) modeling in the voltage-gated sodium ion channel (NaV1.7) inhibitor drug discovery effort to address strategic questions regarding in vitro to in vivo translation of target modulation. Methods PK-PD analysis was applied to data from a functional magnetic resonance imaging (fMRI) technique to non-invasively measure treatm...
TRY plant trait database – enhanced coverage and open accessNARA Subscribed
Plant traits—the morphological, anatomical, physiological, biochemical and phenological characteristics of plants—determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodivers...
Sponges are conspicuous and abundant within the benthic fauna on Caribbean reefs. The ability of these organisms to efficiently capture carbon from particulate sources is well known and the importance of dissolved organic carbon (DOC) uptake has been recognized for several species. We surveyed DOC ingestion by seven sponge species common to Florida Keys reefs using nondisruptive sampling methods on undisturbed individuals. Thr...
172Business clusters are geographic concentrations of companies that provide mutual advantages for their participants. Clusters can include diverse members including competitors, customers, partners, and/or suppliers. In Alaska, wood products business clusters can have unique challenges associated with remote locations, high raw material costs, limited local markets, and potentially long transportation distances. Further, mult...
Pacific Rim Forestry / Silviculture and Forest EcologyNARA Subscribed
Leucaena leucocephala (leucaena) is an important agroforestry tree of tropics and subtropics due to its protein rich foliages, ability to grow on poor soils, and high level of tolerance to various stresses including drought and diseases. We hypothesized that leucaena have a unique set of genes which confer tolerance to various abiotic and biotic stresses and these genes are either absent or not expressed in other legumes that...