Sporotrichosis caused by Sporothrix brasiliensis is a highly virulent zoonotic mycosis rapidly expanding in Brazil, with increasing records in Pará since 2018. The reference diagnosis relies on culture and the time-consuming induction of fungal dimorphism, which delays taxonomic confirmation for weeks. The objective of the study was to develop and validate an in-house spectral library by MALDI-TOF MS for the rapid identificati...

Plant-mediated green synthesis has emerged as a sustainable and cost-effective strategy for the production of gold nanoparticles (AuNPs). In this study, gold nanoparticles were synthesized using an aqueous extract of Virola oleifera resin (AuNPs-Vo), and their synthesis parameters were optimized through factorial experimental design, followed by physicochemical characterization and cytotoxicity assessment. Factorial experiment...

Sporothrix species are the etiological agents of sporotrichosis, an emerging fungal disease of medical and veterinary importance. Molecular surveillance using publicly available databases enables the monitoring of pathogen dissemination and the identification of genetic and epidemiological patterns, particularly in endemic regions. This study aimed to perform an integrative analysis of clinical, epidemiological and phylogeneti...

Biodiversity monitoring programs need to deliver accurate, timely, and actionable predictions. To establish a predictive monitoring program for deep‐sea benthos of the Santos Basin, Brazil, we developed a two‐stage structured model that allowed comparison of biodiversity predictions obtained from environmental simulations (2M‐Sim). We also modeled the environmental variables as a function of spatial and temporal variables and...

β-Lapachone exhibits potent anticancer activity although its clinical application remains limited by toxicity and mechanisms of resistance. Therefore, structural modifications have been explored to improve its pharmacological profile. This study evaluated the cytotoxic, genotoxic, and toxicological effects of the oxime derivative β-lapachone oxime (Oxβ-Lp), together with its predicted pharmacokinetic properties and potential m...

Staphylococcus aureus is a Gram-positive coccus-type bacterium responsible for colonizing various sites of the host’s body, thus generating several pathologies such as pneumonia, osteomyelitis, endocarditis, and even cases of sepsis. Eugenol, dihydroeugenol, guaiacol, and phenol are phenolic compounds with antimicrobial activities, as is the drug metronidazole; therefore, eight substances were synthesized by coupling metronida...

Bees are essential for ecosystem functioning, pollinating many wild and crop plant species. Predicting which species are most vulnerable to global changes, and how their loss may impact ecosystems and human well-being, is critical. Comprehensive information on bee response and effect traits is fundamental to these assessments. However, the Raunkiærian shortfall—insufficient trait data—remains significant for bees, particularly...