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Integrin inhibition differentially remodels vascular networks in lung metastases driven by vessel co-option or angiogenesisNARA Subscribed
Tumor progression depends on an adequate blood supply to sustain oxygen and nutrients delivery. While tumor angiogenesis involves the formation of new blood vessels from pre-existing ones, vessel co-option represents a non-angiogenic vascularization strategy whereby tumor cells utilize pre-existing host vessels. Co-opted vessels have been considered refractory to anti-angiogenic therapies, and pharmacological modulation of co-...
The Asia region harbors exceptional chondrichthyan (shark, ray, and chimaera) diversity but faces intense fishing pressure. The Important Shark and Ray Areas (ISRA) process provides a collaborative, evidence-based framework to identify critical habitats and inform spatial management. We assessed ISRAs across the Bay of Bengal, Southeast Asia, and the Northwest Pacific to characterize their extent, ecological significance, and...
Aim Plant functional traits can influence interaction outcomes between nurse and target plants through a “functional trait match”, which occurs when the traits of nurse plants ameliorate their environment, and target plants possess traits that allow them to benefit from this ameliorated environment. We investigated how the traits of putative nurse species affect interaction outcomes across global drylands and determined the fu...
Specific myogenic microRNAs termed “myomiRNAs” are involved in skeletal muscle development and regeneration, and an obesogenic environment in utero may affect these processes. The present study aimed to determine whether this environment induced variations in the expression levels of myomiRs-31, −133, −136, −206, and −296 and whether the administration of (-)-epicatechin (Epi), an exercise mimetic, could modify these variation...